United States
£ GBP
This comprehensive book examines the chemistry, genetics, and biology of Fusarium mycotoxins. It covers major and minor mycotoxins and other biologically active metabolites that can be harmful to both human and animal health. Past and present research is covered, providing both a historical concept on the topic, as well as guidelines for further research. Descriptions of Fusarium species assist in visual identification of species, while complete profiles will help assess risk as well give a background on geographic trends. And tables summarizing the distribution of mycotoxins among Fusarium species allow for quick reference to mycotoxins and Fusarium species.
Fusarium Mycotoxins: Chemistry, Genetics, and Biology begins by presenting landmarks in the study of Fusarium mycotoxins from 1809 to 2005. These historical case studies and controversies document the relevance of mycotoxins to human and animal health. Also included is a thorough review of the molecular genetics of both trichothecene and fumonisin biosynthesis, presenting more than 15 years of molecular biological research in an accessible form. Part one then reviews the natural occurrence and toxicity of agriculturally important mycotoxins, with historical case studies of suspected mycotoxicoses in humans and animals. These chapters also contain updates on the molecular genetics of additional mycotoxins and the importance of mycotoxins in plant diseases.
This useful reference presents concise descriptions of mycotoxin-producing Fusarium species, as defined by the most recent concepts of fungal species biology and evolution. Each species' report includes a risk assessment based on its mycotoxin profile, occurrence in food and feed crops, and association with human and animal mycotoxicoses. Data on species distribution, mycotoxin profiles, and animal toxicity facilitate risk assessment for food and feed safety.
Fusarium Mycotoxins: Chemistry, Genetics, and Biology will be of interest to agronomists, biological chemists, cereal chemists, food technologists, fungal geneticists, human nutritionists, international agricultural development agencies, molecular microbiologists, mycologists, plant breeders, plant pathologists, toxicologists, veterinary scientists, and advanced students in these fields. In addition, public health regulatory agencies that are interested in assessing and managing risks associated with Fusarium mycotoxins in food and feeds will find this an excellent resource.
Introduction to Fusarium Mycotoxicology
Part One. Fusarium Mycotoxins
Chapter 1. Trichothecenes
Historical Case Studies
Historical Case 1: Alimentary Toxic Aleukia in Russia and Central Asia
Historical Case 2: Akakabi-byo in Japan
Historical Case 3: Swine Feed Refusal in the Central United States
Historical Case 4: The Yellow Rain Controversy
Trichothecene Chemistry
Overview of Trichothecene-Producing Fusarium Species
Identification and Analysis of Trichothecenes
Natural Occurrence of Trichothecenes
In North America
In South America
In Europe
In Africa
In the Middle East and South Asia
In East Asia
In Southeast Asia, Australia, and New Zealand
Trichothecene Genetics
Trichothecene Biosynthetic Pathway
Trichothecene Biosynthetic Enzymes
Trichothecene Biosynthetic Genes
Trichodiene Synthase (TR15)
Cytochrome P450 Monoxygenases
Enzymes that Add or Remove Ester Groups
Transcription Factors and Transporters
Coregulated Genes
Trichothecene Biology
Mechanism of Action of Trichothecenes
Biological Activity of Trichothecenes in Animal Systems
Biological Activity of Trichothcenes in Plant Systems
Applications of Trichothecenes to Plant Breeding
Chapter 2. Zearalenones
Historical Case Study
Case Study: Swine Estrogenic Syndrome in the Central United States
Zearalenone Chemistry
Overview of Zearalenone-Producing Fusarium Species
Identification and Analysis of Zearalenones
Natural Occurrence of Zearalenones
In North America
In South America
In Europe
In Africa
In Asia
In Australia and New Zealand
Zearalenone Genetics
Zearalenone Biosynthesis
Zearalenone Biology
Mechanism of Action of Zearalenones
Biological Activity of Zearalenones in Animal Systems
Biological Activity of Zearalenones in Plant Systems and Applications to Plant Breeding
Chapter 3. Fumonisins
Historical Case Studies
Historical Case 1: Equine Leukoencephalomalacia in the United States
Historical Case 2: Swine Pulmonary Edema in the Central United States
Historical Case 3: Esophageal Cancer in South Africa
Historical Case 4: Neural Tube Defects Along the Texas-Mexico Border
Fumonisin Chemistry
Overview of Fumonisin-Producing Fusarium Species
Identification and Analysis of Fumonisins
Natural Occurrence of Fumonisins
In North America
In South America
In Europe
In Africa
In the Middle East and South Asia
In East Asia
In Southeast Asia and Australia
Fumonisin Genetics
Fumonisin Biosynthetic Pathway
Fumonisin Biosynthetic Genes
Polyketide Synthase (FUM1)
C-3 Carbonyl Reductase (FUM13)
Fumonisin 5-Oxygenase (FUM3)
Tricarballylic Esterification (FUM7, FUM10, FUM11, and FUM14)
Additional Required Genes in the FUM1 Gene Cluster
Additional Coregulated Genes in the FUM1 Gene Cluster
Fumonisin Biology
Mechanism of Action of Fumonisins
Biological Activity of Fumonisins in Animal Systems
Biological Activity of Fumonisins in Plant Systems
Applications of Fumonisins to Plant Breeding
Chapter 4. Other Selected Mycotoxins
Beauvericin
Chemistry
Genetics
Biology
Enniatins
Chemistry
Genetics
Biology
Fusaproliferin
Chemistry
Biology
Fusaric Acids
Chemistry
Biology
Fusarins
Chemistry
Biology
Moniliformin
Chemistry
Genetics
Biology
Chapter 5. Other Selected Metabolites
Acuminatum
Butenolide
Chlamydosporol
Culmorin
Cyclodepsipeptide HA23
Cyclonerodiol
Equisetin
Fusarochromanone
Gibberellins
Naphthoquinones
Sambutoxin
Wortmannin
Part Two. Mycotoxigenic Fusarium Species
Chapter 6. Selected Mycotoxigenic Fusarium Species
Fusarium acuminatum and Fusarium armeniacum
Fusarium acutatum
Fusarium andiyazi
Fusarium anthophilum
Fusarum avenaceum, Fusarium aywerte, and Fusarium nurragi
Fusarium begoniae
Fusarium beomiforme
Fusarium camptoceras
Fusarium chlamydosporum
Fusarium circinatum
Fusarium compactum
Fusarium concentricum
Fusarium crookwellense (syn. Fusarium cerealis)
Fusarium culmorum
Fusarium denticulatum
Fusarium dlamini
Fusarium equiseti
Fusarium fujikuroi
Fusarium globosum
Fusarium graminearum
Fusarium guttiforme
Fusarium konzum
Fusarium kyushuense
Fusarium lateritium
Fusarium moniliforme (see Fusarium verticillioides)
Fusarium napiforme
Fusarium nygamai
Fusarium oxysporum
Fusarium phyllophilum
Fusarium poae
Fusarium proliferatum
Fusarium pseudograminearum
Fusarium sacchari
Fusarium sambucinum
Fusarium semitectum
Fusarium solani
Fusarium sporotrichioides
Fusarium subglutinans
Fusarium thapsinum
Fusarium torulosum
Fusarium tricinctum
Fusarium venenatum
Fusarium verticillioides
Literature Cited
Index
"This book will be of great interest and value to plant pathologists as well as to veterinary and medical toxicologists as all these fields have been incorporated into this book. The fact that part "Literature Cited" counts 759 references shows how broad is the book subject."
– Journal of Plant Protection Research
" [...] brings together most of the relevant available information to help understand this important group of mycotoxigenic moulds [...] particularly useful to undergraduate and post-graduate students to obtain the necessary knowledge on this group of plant pathogens and spoilage moulds."
– Journal of Agricultural Science
" [...] more than a twofold increase in toxin reports for Fusarium species since 1984. One of the greatest events in this period was the isolation and characterization of the most insidious and most highly carcinogenic Fusarium mycotoxin, fumonisin. These developments justify an authoritative new review of the whole topic, a mandate which the book admirably adopts [...] altogether this was a very successful production."
– Nova Hedwigia
"This book will be of interest to agronomists, biological chemists, cereal chemists, food technologists, fungal geneticists, human nutritionists, international agricultural development agencies, molecular microbiologists, mycologists, plant breeders, plant pathologists, toxicologists, veterinary scientists, and advanced students in these fields."
– Practical Hydroponics & Greenhouses
"This is a true work of biological scholarship [...] an excellently written, authoritative, detailed and timely account of mycotoxins. They should command far greater attention as the importance of deficiencies in global food security become ever more apparent. She [author] is to be commended for the time successfully invested in writing this monograph. Biologists with other specialisms will find this a work worthy of their interest."
– Biologist
" [...] highlights new species and newly discovered mycotoxins and really brings to life major advances in the field [...] the book is well organized, which makes the presentation simple and elegant for such a comprehensive and important topic."
– Inoculum
" [...] a well structured, concise collection of up-to-date information on toxigenic species of Fusarium and their toxins [...] This book has to find its way onto the shelves of everyone interested in Fusarium toxins whether they be teachers, students, researchers or involved in legislation and food safety and control."
– Microbiology Today
"The topic, concept and contents of the book can be considered an extraordinarily interesting and up-to-date review of recent progress in the area of Fusarium mycotoxins."
– Czech Mycology
"The general design of the book makes it an ideal reference text with a comprehensive bibliography and thorough index and as such would be ideal for any library [...] the book is compact and concise and very reasonably priced [...] "
– Plant Pathology
"This book has to find its way onto the shelves of everyone interested in Fusarium toxins whether they be teachers, students, researchers or involved in legislation and food safety and control, and it will also provide mycologists with an insight into recent ideas about species concepts in this genus."
– Mycological Research
![Nuevo Diccionario Ilustrado de Micologia [New Illustrated Dictionary of Mycology]](http://mediacdn.nhbs.com/jackets/jackets_resizer_medium/15/157811.jpg?height=150&width=113)
