The Dog and its Genome

About this book

Dogs of different breeds can range remarkably in size, shape, and behaviour, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty-five chapters written by experts in the field include various aspects of morphological and behavioural variation in dogs, their origins and domestication, and their unique value as a model system for many common, but complex human diseases, such as diabetes and cancer.

Contents

BREED CLUBS AND CANINE HISTORY Working Dogs: History and Applications The Kennel Club and the Early History of Dog Shows and Breed Clubs American Breed Clubs and Health Initiatives BREED CHARACTERISTICS AND MORPHOLOGY Morphological Variation in the Dog Genetic Analysis of the Canid Skeleton: Morphological Loci in the Portuguese Water Dog Population Morphology and Behavior: Are They Coupled at the Genome Level? CANINE ORIGINS From Wild Wolf to Domestic Dog mDNA Studies of the Origin of Dogs Understanding Genetic Relationships among Purebred Dogs: The PhyDo Project GENOMICS AND GENOME ORGANIZATION Karyotype and Chromosomal Organization The Dog Genome: Sequence, Evolution, and Haplotype Structure SINEs of Canine Genomic Diversity The Dog Olfactory and Vomeronasal Receptor Repertoires The Canine Major Histocompatibility Complex GENETIC DISEASE AND GENE MAPPING Breed-specific Hereditary Diseases and Genetic Screening Models, Mutants, and Man: Searching for Unique Phenotypes and Genes in the Dog Model of Inherited Retinal Degeneration Copper Toxicosis in Bedlington Terriers Cystinuria Molecular Genetics of Dilated Cardiomyopathy Sex Chromosomes, Sexual Development, and Sex Reversal in the Dog QTL Mapping Using Crossbreed Pedigrees: Strategies for Canine Hip Dysplasia CANCER Breed-specific Canine Lymphoproliferative Diseases Cancer Biology in Dogs GENE THERAPY Gene Therapy for Metabolic Inherited Diseases in Dogs BEHAVIOR Behavioral Genetics of Dog Cognition: Human-like Social Skills in Dogs Are Heritable and Derived The Genetics of Domesticated Behavior in Canids: What Can Dogs and Silver Foxes Tell Us about Each Other? Appendix Index

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