300 pages, 62 illus
Mechanisms in Transcriptional Regulation provides a concise discussion of the fundamental concepts in transcription and its regulation. It covers RNA polymerases, transcriptional machinery, mechanisms of transcriptional activation, the histone code hypothesis, the epigenetic control of transcription, and combinatorial control in signaling and development.
Preface 1. The Vocabulary of Transcription 2. RNA Polymerases and the Transcription Cycle 3. The Eukaryotic Basal Machinery 4. Mechanisms of Transcriptional Activation 5. Transcriptional control through the modification of chromatin structure 6. The Epigenetic Control of Transcription 7. Combinatorial Control in Development and Signal Transduction
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Albert J. Courey has taught undergraduate and graduate students about mechanisms of transcription and its regulation for the last 16 years as Professor of Biochemistry at UCLA. He also directs an active research program examining the mechanisms of transcriptional regulation during fruit fly development.