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Protein Condensation: Kinetic Pathways to Crystallization and Disease

An introduction to a rapidly expanding field
Reviews current experimental work for several important proteins to provide cutting-edge summary of current experimental knowledge
Contains works from many different disciplines

By: James D Gunton (Author), Andrey Shiryayev (Author), Daniel L Pagan (Author)

296 pages, colour plates, 112 b/w illustrations, tables

Cambridge University Press

Hardback | Sep 2007 | #169255 | ISBN-13: 9780521851213
Availability: Usually dispatched within 6 days Details
NHBS Price: £103.00 $125/€115 approx

About this book

The quest to understand the condensation of proteins from solutions is a rapidly evolving field. The purpose of Protein Condensation is to bring to an interdisciplinary audience the state-of-the-art in current research. The first part of Protein Condensation deals with issues related to the production of high quality protein crystals from solution. Since protein function is determined by structure, high quality protein crystals must be grown in order to determine their structure by X-ray crystallography. Protein Condensation also discusses diseases that occur due to undesired protein condensation, an increasingly important subject. Examples include sickle cell anemia, cataracts and Alzheimer's disease. Current experimental and theoretical work on these diseases is discussed, which seeks understanding at a fundamental, molecular level, to prevent the undesired condensation from occurring.

"[...] the text covers just about anything a researcher would need to know of the many research areas of protein crystallisation. From statistical tests to theoretical models and mathematics, Gunton et al. appear to include the lot."
- Journal of Biological Education



1. Introduction
2. Globular protein structure
3. Experimental methods
4. Thermodynamics and statistical mechanics
5. Protein-protein interactions
6. Theoretical studies of equilibrium
7. Nucleation theory
8. Experimental studies of nucleation
9. Lysozyme
10. Some other globular proteins
11. Membrane proteins
12. Crystallins and cataracts
13. Sickle hemoglobin and sickle cell anemia
14. Alzheimer's disease


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J. D. Gunton is Joseph A. Waldschmitt Professor of Physics at Lehigh University in Pennsylvania. He is the author of approximately 200 articles in refereed journals on equilibrium and nonequilibrium phase transitions. He is a Rhodes Scholar and a Danforth Fellow, and a Fellow of the American Physical Society.

A. Shiryayev is a doctoral candidate at Lehigh University. He has already published several refereed articles that deal with the condensation of globular proteins.

D. L. Pagan received is PhD degree from Lehigh University in 2005. He has authored several refereed articles on the condensation of globular proteins.

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