Gene and Cell Therapy

About this book

Gene and Cell Therapy provides comprehensive coverage of all aspects of the tools and state-of-the-art technologies that are currently available. Written by international leaders in the field, this third edition features 12 additional chapters that address such new topics as gene and cell therapies for diabetes, therapies supporting nanotechnology, siRNA therapeutics, alpha viruses, dendrimers, gene and cell therapies for cardiovascular disease, promising new cell and gene therapy trials, human embryonic stem cell research, and tissue engineering. All chapters in the text have been substantially updated and revised to reflect the latest information available in the field.

Contents

Retroviral Vectors. Adenoviral Vectors. Modified Adenoviral Vectors. Helper-Dependent Adenoviral Vectors. Adeno-Associated Vectors. Herpes Simplex Viral Vectors. Lentiviral Vectors. Alpha-viruses. Myoblasts and Regulatable Vectors. Vaccinia Viral Vectors. Baculovirus Vectors. Bacterial Vectors. Polymers (Non-Viral Delivery). Polymers (Non-Viral Delivery). Targeted Polymers (Non-Viral Delivery). Dendrimers. In Vivo Electroporation (Non-Viral Delivery). Gene Gun Delivery. Optimization for Efficient Non-Viral Delivery. Molecular Interactions in Lipids, DNA, and Complexes. Ribozymes. Antisense Oligonucleotide Therapeutics. siRNA Therapeutics. Suicide Gene Therapy. Selectable Markers. Inducible Gene Expression (Gene Switches). In Vivo Imaging. Gene Transfer in Hematopoietic Stem Cells (HSCs). Gene Therapy for Hematopoietic Disorders. Gene Therapy for Cardiovascular Disease. Gene and Cell Therapies for Cardiovascular Disease. Cancer Gene Therapy. Airway Epithelial Gene Transfer. Gene Therapy for Neurological Disease. Gene Therapy for Metabolic Diseases. Gene Therapy for the Treatmetn of HIV-1 Infection. Gene Therapy for Skin Disorders. Gene Therapy for Blindness. DNA Vaccines. Gene and Cell Therapy for Diabetes. Gene and Cell Therapies Supporting Nanotechnology. Cardiovascular Gene Therapy. Clinical Trials Using Oncolytic Viruses. Gene and Cell Therapies for the Treatment of Cancer. Clinical Trials using p53 Gene Therapy. Ex Vivo Gene Therapy for Alzheimer's Disease. Clinical Application of Synthetic Delivery Vectors. Other Promising Cell and/or Gene Therapy Trial. Another Promising Cell and/or Gene Therapy Trial. FDA Regulatory Aspects and Regulations for Gene Therapy. Use of Genetically Engineered Immunoisolated Cells for the Treatment of Central Nervous System (CNS) Disorders. Hematopoietic Progenitor Cells (HSCs). Gene Marking Studies in Hematopoietic Stem Cells (HSCs). Gene and Cell-based Vaccination. Human Embryonic Stem Cells. Tissue Engineering.

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Biography

Baylor College of Medicine, Houston, TX, USA