416 pages, Col & b/w figs, tabs
The first part of this volume focuses on the plant Cannabis sativa, its active ingredients, and the discovery of cannabinoid receptors as well as the therapeutic applications of activating, or blocking, the receptors. Following an overview of the plant, its medicinal uses and its preparations, further chapters cover biosynthetic pathways, pharmacological properties, cannabis-based medicine, toxicology, cannabis prohibition and clinical situations where blocking the cannabinoid receptors might be beneficial.
The second part covers the journey from humans to plants, analyzing anandamide, as well as other endocannabinoids and endocannabinoid congeners, biosynthetic pathways, current knowledge of FAAH-1, FAAH-2, monoglyceride lipase and NAAA, concluding with new areas of research.
The most attractive features of the book are that each chapter is well organized, generally well written and clear, and that it provides an extensive, up-to date and comprehensive account of both the cannabinoids and the endogenous cannabinoid system. The book tackles a very complex story in a manner that will be easily understood by readers new to this field. At the same time, since it provides an interesting analysis of many aspects of cannabis and its components, and of the endocannabinoid system, more experienced researchers will also find useful information to extend their knowledge of cannabinoids. (ChemMedChem, 2010)
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