459 pages, 182 illustrations
This book examines the relationship between the embryo and its environment and demonstrates how development in nature is different from development in the laboratory. The coverage provided intersects numerous disciplines and provides new and important perspectives on Ecology, Conservation Biology, Cancer Biology, Ageing Research, Medicine and Evolution.
'Overall, a masterful synthesis! It's one of those things that makes one say, "Damn, I wish I had written that!"' - Fred Nijhout, Duke University, USA 'A unique, thought-provoking, and clearly written treatment, at the molecular level, of the environment's influence on embryonic development and the paths of evolutionary change.' - John Gerhart, University of California, Berkeley, USA 'This is an incredible piece of work, and something that is sorely needed, right now.' - Mary Tyler, University of Maine, USA 'This is an extraordinary work ! first-class conceptually and pedagogically.' - John Beatty, University of British Columbia, Canada
PART I: ENVIRONMENTAL SIGNALS AND NORMAL DEVELOPMENT The Environment as a Normal Agent in Producing Phenotypes How Agents in the Environment Effect Molecular Changes in Development Developmental Symbiosis: Co-Development as a Strategy for Life Embryonic Defenses: Survival in a Hostile World PART II: ECOLOGICAL DEVELOPMENTAL BIOLOGY AND DISEASE STATES Teratogenesis: Environmental Assaults on Development Endocrine Disruptors The Epigenetic Origin of Adult Diseases PART III: TOWARD A DEVELOPMENTAL EVOLUTIONARY SYNTHESIS The Modern Synthesis: Natural Selection of Allelic Variation Evolution through Developmental Regulatory Genes Environment, Development, and Evolution: Toward a New Synthesis CODA: Philosophical Concerns Raised by Ecological Developmental Biology APPENDX A: Lysenko, Kammerer, and the Truncated Tradition of Ecological Developmental Biology APPENDIX B: The Molecular Mechanisms of Epigenetic Change APPENDIX C: Writing Development Out of the Modern Synthesis APPENDIX D: Epigenetic Inheritance Systems: The Inheritance of Environmentally Induced Traits
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SCOTT A. GILBERT, Howard A. Schneiderman Professor of Biology, Martin Laboratories, Swarthmore College, Swarthmore, PA, USA DAVID EPEL, Jane & Marshall Steel Jr. Professor in Marine Sciences, Hopkins Marine Station, Stanford University, Monterey, CA, USA