By: Gunter Meister
The first-ever advanced text on RNA biology captures all the excitement of this booming field. Divided into three parts, on coding RNA, non-coding RNA, and RNomics, both the traditional roles of RNA in the transmission and regulation of genetic information and the newly discovered functions of small RNA species in pathogen defense, cell differentiation and higher-level genomic regulation are competently explained and put into perspective.
Introduction PART 1: mRNA BIOLOGY Transcription of pre-mRNAs Capping of the pre-mRNA 5? end 3? end processing of pre-mRNAs Splicing of eukaryotic pre-mRNAs mRNA export from the nucleus to the cytoplasm Translation Deadenylation of the mRNA mRNA decapping mRNA decay pathways mRNA quality control PART 2: NON-CODING RNA BIOLOGY Ribosomal RNAs (rRNAs) and the biogenesis of ribosomes Transfer RNAs (tRNAs) The 7SL RNA and the signal recognition particle Regulation of transcription: the 7SK small nuclear RNA Small nucleolar RNAs (snoRNAs) Spliceosomal small nuclear RNAs (snRNAs) Small non-coding RNAs and the mechanism of gene silencing Long non-coding RNAs RNA editing Ribozymes ? catalytic RNA molecules Riboswitches and RNA sensors RNomics APPENDIX Answers to questions
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Gunter Meister is the head of the research group "RNA Biology" at the Max Planck Institute of Biochemistry in Martinsried (Germany). He obtained his PhD degree from the University of Munich and the Max Planck Institute of Biochemistry, working on RNA-protein complexes. Thereafter, he joined the group of Tom Tuschl at the Rockefeller University in New York (USA), where he worked on RNA interference and small non-coding RNAs. Gunter Meister has received an EMBO long-term fellowship as well as an Emmy Noether fellowship from the Deutsche Forschungsgemeinschaft.
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