Books  Animal & General Biology  Genetics 

Guide to the Human Genome

By: Stewart Scherer (Author)

1008 pages, 212 b/w illustrations, tables

Cold Spring Harbor Laboratory Press

Paperback | Nov 2010 | #191657 | ISBN-13: 9780879699444
Availability: Usually dispatched within 6 days Details
NHBS Price: £78.99 $100/€93 approx

About this book

Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive resource that provides easy access to information about human genes and their roles in specific processes. With numerous illustrations and tables, each of the nearly 300 sections of the Guide describes genes involved in a specific pathway, process, or structure – from the molecular and cellular levels to developmental and physiological processes. The Guide will be useful to researchers looking to connect sequence data with functional information, and can be used in parallel with traditional texts in undergraduate and graduate courses to provide a genomics dimension and experience of identifying genes underpinning processes of interest.


Contents

Preface
1. Introduction
    Reference Protein Set
    Data Sets for Comparative Genomics
    About the Figures
    Searching Gene Names or Descriptions
    Protein Searches with BLASTP
    Searching the Text
 
2. Exploring the Genome
    Chromosomes and DNA (includes the mitochondrial genome)
    Noncoding RNAs
    Gene Structure
    Protein Composition and Structure
    Polymorphism
    Domain Structure of Proteins
    Gene Families
    Comparative Genomics
    Additional Reading
 
3. Metabolism
    Metabolism and Evolution
    Hexokinases and Initial Sugar Metabolism
    Glycolysis (includes gluconeogenesis)
    TCA Cycle
    Oxidative Phosphorylation (includes the electron transport chain)
    Pentose Phosphate Pathway
    Glycogen
    Galactose and Lactose
    N-Acetyl Sugars and Hyaluronan
    Alcohol and Aldehyde Dehydrogenases
    Fatty Acid Synthesis
    Arachidonate, Prostaglandins, and Leukotrienes
    Fatty Acid Oxidation and Ketone Bodies
    Lipid Metabolism
    Sphingomyelin, Ceramides, and Glycolipids
    Cholesterol Biosynthesis
    Steroid Hormones
    Bile Acids and Other Cholesterol Derivatives
    Amino Acid Biosynthesis and Selected Derivatives
    Amino Acid Catabolism
    Urea Cycle, Nitric Oxide, and Polyamines
    Pyrimidine Biosynthesis and Catabolism (includes salvage pathways)
    Purine Biosynthesis and Catabolism (includes salvage pathways)
    Nucleotide Pathways
    Pteridines and Molybdopterin
    Heme
    Vitamin Pathways, Coenzymes, and 1-Carbon Metabolism
    Cytochrome P450 Enzymes (includes diflavin oxidoreductases)
    Phosphatases and Sulfatases
    Glutathione Pathways (includes related redox reactions)
    Xenobiotic Pathways
    Additional Enzymes and Related Sequences (includes cytochrome b5 and the ? / ? hydrolase fold family)
    Additional Reading
 
4. DNA Replication, Recombination, Repair, and Chromatin
    DNA Replication Systems
    DNA Polymerases
    Replication Proteins
    Telomere Functions
    DNA Methylation
    DNases, Recombination, and DNA Repair
    DNA Transposon and Retrovirus-related Sequences (includes LINE and SINE elements)
    Histones, Related Proteins, and Modifying Enzymes
    Nonhistone Chromosomal Proteins (includes protamines, transition proteins, HMG proteins, chromodomain family)
    Centromere Proteins
    Additional Reading
 
5. Transcription and RNA Processing
    RNA Metabolism
    RNA Polymerase and General Transcription Factors
    hnRNP
    Small RNAs in RNA Processing
    Capping and Splicing
    Polyadenylation
    RNA Editing and Other RNA Modifications
    RNases and RNA Stability
    DEAD / H Helicase Family
    RNA-binding Proteins
    Additional Reading
 
6. Translation and Protein Modification
    Translation and Modification Systems
    Codon Usage
    tRNAs
    tRNA Enzymes
    Ribosomes
    Translation Factors
    Selenium Proteins
    Protein Glycosylation (includes transferases involved in synthesis of glycolipids)
    GPI Anchoring
    Prenylation and Related Modifications
    Transglutaminases
    Peptidylprolyl Isomerases
    polyADP-Ribose Polymerase Family
    Additional Protein Modifications (includes repair reactions)
    Additional Reading
 
7. Proteases
    Overview of the Proteases
    Serine Proteases
    Cysteine Proteases
    Metalloproteases
    Aminopeptidases
    Carboxypeptidases
    Aspartic Proteases
    Peptide-processing Enzymes
    Protease Inhibitors
    Ubiquitin and Related Protein Modifications
    Cullins and SCF Complexes (includes VHL pathway)
    Proteasome
    Additional Reading
 
8. Structural Proteins
    Origins of Structural Proteins
    Actin and Related Proteins
    Myosin
    Tubulin and Microtubules
    Kinesins
    Dynein and Dynactin
    Collagen
    Keratins
    Late Cornified Envelope Family
    Spectrin and Plectin Families
    Ankyrin Family
    Kelch Family
    Additional Structural Proteins (includes IFT proteins)
    Additional Reading
 
9. Protein Interaction Domain Families
    Domains, Motifs, and Composition
    LIM Domain Proteins
    PDZ Domain
    WD Repeat Proteins
    Ring Finger Proteins
    Tripartite Motif Family
    Zinc Finger Proteins
    Bromodomain Family
    Leucine-rich Repeat Family
    Coiled-Coil Proteins
    Tetratricopeptide Domains
    WW Domain
    Additional Interaction Domain Families (includes IQ, sterile ?, COMM, DEP, Tudor, BTB, EH, sushi, DENN, RUN, LEM)
    Additional Reading
 
10. Stress Response and Homeostasis
    Conservation of Stress Responses
    Heat-Shock Proteins and Chaperonins
    Oxygen Sensing and Hemoglobin
    Solute Carrier Families (membrane transporters)
    ATP-binding Cassette Proteins
    Metallothioneins
    Iron, Copper, and Arsenic Metabolism
    Lipoproteins
    Oxysterol-binding Protein Family
    Carbonic Anhydrases
    Aquaporins
    Sodium, Potassium, and Calcium Membrane ATPases
    Amphipath-transporting ATPase Family
    Additional Stress Response Functions
    Additional Reading
 
11. Signals
    Signaling Pathways and Microbial Pathogenesis
    G-Protein-coupled Receptors
    Peptide and Protein G-coupled Signals
    G Proteins
    Inositol Pathways (includes protein kinase C)
    Ras
    Rho and Rac
    Rab
    Ran and Rag
    ADP-Ribosylation Factors
    Additional Guanine Nucleotide-binding Proteins
    Cyclic Nucleotides
    Calmodulin and Calcium
    TNF and Related Signals (includes NGF)
    Receptor Tyrosine Kinases
    Non-Receptor Tyrosine Kinase Pathways
    Protein Tyrosine Phosphatases
    MAP Kinase Pathways
    Additional Serine / Threonine Protein Kinases
    Serine / Threonine Protein Phosphatases
    Protein Kinases
    Phosphatases
    CREB / ATF Family
    Jun / Fos Complexes
    NF-?B Pathway
    mTOR Pathway
    Nucleotide and Nucleoside Receptors
    Signalosome
    Integrins (includes tetraspanins)
    Netrins and Laminins
    Fibronectin Family
    Semaphorins
    14-3-3 Proteins
    BCL2 Pathways, Caspases, and Programmed Cell Death
    Nuclear Receptors
    Additional Signal Responses
    Additional Reading
 
12. Cell Structure and Organelles
    Partitioning and Organelles
    Cytoskeleton
    Nucleus and Nucleolus
    Centrosome
    ER, Golgi, and the Secretory Pathway (includes endosome traffic)
    Mitochondria
    Peroxisomes
    Lysosomes and Related Organelles
    Gap Junctions and Tight Junctions
    Additional Membrane Functions (includes autophagy, lipid transfer, dynamin family, scavenger receptors, lipid rafts, endocytosis)
    Additional Reading
 
13. Cell Cycle
    Eukaryotic Cell Cycle Control
    Cyclins and Related Functions
    Myc and Related Functions
    p53 Pathway
    RB1 and Related Functions
    E2F Pathways
    Anaphase-promoting Complex
    Spindle, M phase, and Meiosis
    Additional Cell Cycle Functions (includes other CDC genes, growth arrest genes)
    Additional Reading
 
14. Development
    Gene Families and Development
    Stem Cells and Early Development
    Left–Right Axis
    Hedgehog and Related Pathways
    Notch Pathway
    Wnt Signals
    Planar Cell Polarity (includes Bardet–Biedl syndrome loci and cilia formation)
    Homeobox and Related Proteins
    HOX Genes
    FOX Family
    SOX Family
    POU Domain
    T Box Family
    PHD Finger Proteins
    Krüppel-related Zinc Finger Proteins
    Helix-Loop-Helix Transcription Factors
    Ephrins and Ephrin Receptors
    Epidermal Growth Factor
    Fibroblast Growth Factors
    TGF-? Family
    Growth Hormone and Related Hormones
    Cadherins and Related Proteins
    Melanoma Antigen Family
    Hematopoiesis and Erythrocytes
    Ets Family
    Additional Genes in Development (includes MAF family, doublesex-related proteins, AP-2 transcription factors, MEF family, tubby family, Sprouty family, carcinoembryonic antigen family, thrombospondin repeat family, MAM domain, chordin family, EYA family, retinoic acid, LY6 family, immunoglobulin-related proteins)
    Noncoding RNAs and Development
    MicroRNAs
    Additional Reading
 
15. Organs and Tissues
    Organs and Hormones
    Extracellular Matrix
    Bone and Related Tissues (includes parathyroid functions)
    Skin and Related Tissues
    Pituitary
    Adrenals
    Thyroid and Thyroid Hormone Receptor
    Adipose Tissue
    Cardiovascular System
    Lung
    Lacrimal and Salivary Glands
    Liver
    Pancreas and Insulin (includes insulin receptor)
    Stomach, Small Intestine, and Colon
    Kidney (includes bladder)
    Prostate
    Testes and Sperm
    Mammary Tissues
    Ovary, Uterus, and Placenta
    Additional Reading
 
16. Nervous System
    Gene Families and the Nervous System
    Sodium Channels (includes voltage-gated proton channel)
    Potassium Channels
    Calcium and TRP Cation Channels
    Chloride Channels
    Acetylcholine
    GABA and Glycine
    Glutamate
    Catecholamines
    Serotonin (includes melatonin)
    Histamine
    Synapses
    Olfactory Receptors
    Taste Receptors
    Auditory and Vestibular Functions
    Photoreceptors and Related Functions
    Crystallins and Other Eye Proteins
    Neurons
    Oligodendrocytes and Myelin
    Cerebellum
    Hypothalamus
    Circadian Rhythms
    Additional Brain Proteins (includes ? amyloid, Huntington’s disease, prion protein, fragile X)
    Muscle
    Additional Reading
 
17. Host Defense
    Innate and Adaptive Immunity
    Mucins
    Lectin Families
    Toll-like Receptors
    Pyrin and Associated Functions
    Complement
    Fc Receptors
    MS4 Family
    Superoxide Pathway
    HLA and Related Proteins
    Additional Immunoglobulin-related Receptors (includes NK cell receptors)
    Butyrophilin Family
    Interleukins and Their Receptors
    Interferon
    Chemokines and Their Receptors
    Macrophages and Monocytes
    Neutrophils, Eosinophils, and Basophils (includes mast cells)
    T cells (includes thymus)
    B cells
    Coagulation
    Platelets and Megakaryocytes (includes PDGF receptor)
    Additional Host Defense Functions (includes cytosine deaminase-related enzymes, selectin family, C-reactive protein family, secretoglobins, defensins, peptidoglycan recognition family)
    Additional Reading
 
Appendices
    Retroviral Oncogene Homologs
    Y-linked Genes
    Major Disease Loci
    Common Drug Targets
    Viral Receptors
    Proteins Measured in Common Diagnostic Tests
    Additional Conserved Proteins
    Proteins Absent from the Reference Set
    Additional Reading
 
Gene index


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