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About this book
Provides a basic introduction to the ideas underlying classical and molecular genetics and then describes the purpose of the Human Genome Project, its approach, its triumphs, its technological pitfalls and its ultimate implications for society.
Contents
What is the Genome Project? Classical Linkage Mapping Modem Linkage Mapping with Polymorphic DNA Markers - A Tool for Finding Genes Informativeness of Polymorphic DNA Markers by Carl E. Hildebrand, David C. Torney, and Robert P. Wagner Maps, Markers, and the Five-Year Goals Physical Mapping - A One-Dimensional Jigsaw Puzzle The Polymerase Chain Reaction and Sequence-tagged Sites by Norman A. Doggett YAC Library Pooling Scheme for PCR-based Screening by David J. Balding and David C. Torney cDNAs and Expressed Genes Technological Challenges in the Genome Project DNA Sequencing Implications for Biology and Society Unraveling the Chromosome by E. Morton Bradbury Various Classes of Human Repetitive DNA Sequences Collaborations on the Isolation of Disease Genes o Chromosome 16 What's Different about Chromosome 16? by Raymond L. Stallings and Norman A. Doggett Mapping Chromosome by Deborah Grady Libraries from Flow-sorted Chromosomes by Larry L. Deaven Decades of Nonlinearity: The Growth of DNA Sequence Data by Christian Burks, Michael J. Cinkosky, and Paul Gilna SCORE: A Program for Computer-Assisted Scoring of Southern Blots by T. Michael Cannon, Rebecca J. Koskela, Christian Burks, Raymond L. Stallings, Amanda A. Ford, Philip E. Hempfner, Henry T. Brown, and James W. Fickett SIGMA: A System for Integrated Genome Map Assembly by Michael J. Cinkosky, James W. Fickett, William M. Barber, Michael A. Bridgers, and Charles D. Troup Electronic Data Publishing in GenBank by Michael J. Cinkosky, James W. Fickett, Paul Gilna, and Christian Burks Single-Molecule Spectroscopy in Solution by Steven A. Soper, Lloyd M. Davis, and E. Brooks Shera.
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