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Numerical Methods for the Life Scientist: Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB

By: Heino Prinz

149 pages, 52 colour & 9 b/w illustrations

Springer-Verlag

Hardback | Aug 2011 | #194358 | ISBN-13: 9783642208195
Availability: Usually dispatched within 1-2 weeks Details
NHBS Price: £104.50 $132/€123 approx

About this book

Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.


Contents

Contents

1 Introduction
2 The Basics
3 Classical Analytical Solutions
4 Getting Started with Octave
5 Equilibrium Binding
6 Binding Kinetics
7 Enzyme Kinetics
8 Fitting the Data

Appendix: Installing GNU Octave for Mac OS and Linux
Index

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