Principles of Molecular Virology

About this book

Principles of Molecular Virology, Sixth Edition, provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. This fully updated edition explores and explains the fundamental aspects of virology, including the structure of virus particles and genome, replication, gene expression, infection, pathogenesis and subviral agents. In addition, this update reflects advances made in the field, including HIV pathogenesis, cryoelectron microscopy, bioinformatics, and RNA interference.

Contents

    Preface to the Sixth Edition
        Reference
    Chapter 1. Introduction
        Intended Learning Outcomes
        What Are Viruses?
        Are Viruses Alive?
        The History of Virology
        Living Host Systems
        Cell Culture Methods
        Serological/Immunological Methods
        Ultrastructural Studies
        Molecular Biology
        Further Reading
    Chapter 2. Particles
        Intended Learning Outcomes
        The Function and Formation of Virus Particles
        Capsid Symmetry and Virus Architecture
        Helical Capsids
        Icosahedral (Isometric) Capsids
        Enveloped Viruses
        Complex Virus Structures
        Protein–Nucleic Acid Interactions and Genome Packaging
        Virus Receptors: Recognition and Binding
        Other Interactions of the Virus Capsid with the Host Cell
        Summary
        Further Reading
    Chapter 3. Genomes
        Intended Learning Outcomes
        The Structure and Complexity of Virus Genomes
        Molecular Genetics
        Virus Genetics
        Virus Mutants
        Genetic Interactions between Viruses
        Nongenetic Interactions between Viruses
        Small DNA Genomes
        Large DNA Genomes
        Positive-Strand RNA Viruses
        Negative-Strand RNA Viruses
        Segmented and Multipartite Virus Genomes
        Reverse Transcription and Transposition
        The Virome—Evolution and Epidemiology
        Summary
        Further Reading
    Chapter 4. Replication
        Intended Learning Outcomes
        Overview of Virus Replication
        Investigation of Virus Replication
        The Replication Cycle
        Summary
        Further Reading
    Chapter 5. Expression
        Intended Learning Outcomes
        Expression of Genetic Information
        Control of Prokaryote Gene Expression
        Control of Expression in Bacteriophage ?
        Control of Eukaryote Gene Expression
        Genome Coding Strategies
        Transcriptional Control of Expression
        Posttranscriptional Control of Expression
        Summary
        Further Reading
    Chapter 6. Infection
        Intended Learning Outcomes
        Virus Infections of Plants
        Immune Responses to Virus Infections in Animals
        Viruses and Apoptosis
        Interferons
        Evasion of Immune Responses by Viruses
        Virus–Host Interactions
        The Course of Virus Infections
        Prevention and Therapy of Virus Infection
        RNA Interference
        Viruses as Therapeutics
        Chemotherapy of Virus Infections
        Summary
        Further Reading
    Chapter 7. Pathogenesis
        Intended Learning Outcomes
        Mechanisms of Cellular Injury
        Viruses and Immunodeficiency
        Virus-Related Diseases
        Bacteriophages and Human Disease
        Cell Transformation by Viruses
        Cell Transformation by Retroviruses
        Cell Transformation by DNA Viruses
        Viruses and Cancer
        New and Emergent Viruses
        Zoonoses
        Bioterrorism
        Summary
        Further Reading
    Chapter 8. Subviral Agents: Genomes without Viruses, Viruses without Genomes
        Intended Learning Outcomes
        Satellites and Viroids
        Prions
        Pathology of Prion Diseases
        TSE in Animals
        Human TSEs
        Molecular Biology of Prions
        Summary
        Further Reading
    Appendix 1. Glossary and Abbreviations
    Appendix 2. Classification of Subcellular Infectious Agents
    Appendix 3. The History of Virology
    Index

Customer Reviews

Biography

Dr. Alan J. Cann has worked in both the U.K. and U.S.A. teaching undergraduate, postgraduate, and medical students. He is currently a Senior Lecturer in Biological Sciences at the University of Leicester where his research interests include pedagogic research and science communication.