Extracellular Matrix Biology

About this book

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis.

Written and edited by experts in the field, this volume covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis.

Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.

Contents

Preface

- Overview of the Matrisome-An Inventory of Extracellular Matrix Constituents and Functions
- Basement Membranes: Cell Scaffoldings and Signaling Platforms
- The Collagen Family
- Heparan Sulfate Proteoglycans
- The Thrombospondins
- Tenascins and the Importance of Adhesion Modulation
- Fibronectins, Their Fibrillogenesis and In Vivo Functions
- Integrin Structure, Activation, and Interactions
- Crosstalk Among TGFbeta Signaling Pathways, Integrins, and the Extracellular Matrix
- Molecular Architecture and Function of Matrix Adhesions
- Genetic Analyses of Integrin Signaling
- Integrins and Extracellular Matrix in Mechanotransduction
- Integrins in Cell Migration
- Extracellular Matrix Degradation and Remodeling in Development and Disease
- Extracellular Matrix in Development: Insights from Mechanisms Conserved between Invertebrates and Vertebrates
- Angiogenesis
- Extracellular Matrix: Functions in the Nervous System
- Cell-Extracellular Matrix Interactions in Normal and Diseased Skin
- Extracellular Matrix Proteins in Hemostasis and Thrombosis

Index

Customer Reviews