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The Nucleus: A Subject Collection from Cold Spring Harbor Perspectives in Biology

Edited By: Tom Mistelli and David L Spector

517 pages, 82 colour & 17 b/w illustrations

Cold Spring Harbor Laboratory Press

Hardback | Nov 2010 | #197267 | ISBN-13: 9780879698942
Availability: Usually dispatched within 6 days Details
NHBS Price: £106.00 $134/€126 approx

About this book

The nucleus of a cell contains its DNA and is the site where DNA replication, transcription, and RNA processing take place. Nuclei have many domains but lack the membrane-bound organelles characteristic of the cytoplasm. Instead, nuclear bodies appear to dynamically self-organize, assembling and disassembling according to the functional demands of the cell.

Written and edited by experts in the field, this volume includes contributions discussing the relationship between nuclear structure and function, the various nuclear bodies that have been identified, and the organization of the nuclear lamina and nuclear pore complex. Other contributions examine the higher-order organization of chromatin within the nucleus and the dynamics of DNA replication, transcription, DNA repair, and RNA transport.

Including a historical introduction to the field and discussion of the numerous pathological conditions involving disruption of nuclear structure and function, this volume is essential reading for all molecular and cell biologists, as well as pathologists interested in the role of nuclear architecture in disease.

This book is a 'must read' for anyone working on nuclear dynamics, serving as general background in a cover-to-cover reading or as a reference with citations of the pertinent literature for a given subject. This book is a nice sequel to the Cold Spring Harbor Symposium volume on the same subject...this book is highly recommended as worth having on one's bookshelf. It is a valuable resource.
- Nucleus

"The 28 chapters are organized to provide a comprehensive overview of nuclear compartments and their components (e.g. nuclear membrane, nuclear pore complex, chromosome territories, Cajal body, nucleolus), to discuss how this organization relates to function (transcription, DNA replication and repair, RNA processing) and to describe the defects in nuclear organization in human disease. The focus is primarily on the nucleus in mammalian cells, but there are also discussions on other simpler model organisms - budding yeast, Caenorhabditis elegans and Drosophila. Each chapter is relatively short and accessible, making this a great resource to dip into. Illustrations are used sparingly but are well chosen....if you interest in the nucleus is piqued, then this book is a good place to start."
- Development

"...Misteli is one of the most creative and productive recent arrivals in the nucleus field, as is his former postdoc mentor, David Spector....every chapter in the book were written by undeniable world leaders....The coverage is complete in that there is no structure or function of the nucleus that does not have a chapter....the book has all of the hallmarks of the fine publishing house that is Cold Spring Harbor Laboratory Press....The result is a book about the nucleus that will not be surpassed anytime soon."
- The FASEB Journal


Contents

Preface

OVERVIEW
- The Nucleus Introduced

THE NUCLEAR PERIPHERY
- The Nuclear Envelope
- Nuclear Lamins
- Lamin-binding Proteins
- The Nuclear Pore Complex and Nuclear Transport

CHROMOSOMES & CHROMATIN
- Chromosome Territories
- Gene Positioning
- Chromatin Higher-order Structure and Dynamics
- Nuclear Organization and Dosage Compensation
- The Budding Yeast Nucleus
- Nuclear Functions of Actin

NUCLEAR BODIES
- The Nucleolus
- Nuclear Speckles
- The Cajal Body and Histone Locus Body
- PML Nuclear Bodies
- The Perinucleolar Compartment
- Paraspeckles
- Nuclear Stress Bodies
- Orphan Nuclear Bodies
- Biogenesis of Nuclear Bodies

FUNCTIONAL ORGANIZATION
- Organization of Transcription
- Organization of DNA Replication
- DNA Damage Response
- RNA Processing and Export

NUCLEAR ARCHITECTURE IN DIFFERENTIATION AND DISEASE
- Diseases of the Nuclear Envelope
- Higher-order Genome Organization in Human Disease
- Nuclear Ataxias
- Developments in RNA Splicing and Disease

APPENDIX
Tables of Data on the Nucleus

Index

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