Books  Animal & General Biology  Genetics 

Toxicology and Epigenetics

By: Saura C Sahu (Editor)

658 pages, b/w illustrations, tables

John Wiley & Sons

Hardback | Sep 2012 | #199144 | ISBN-13: 9781119976097
Availability: Usually dispatched within 5 days Details
NHBS Price: £190.00 $239/€226 approx

About this book

Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.

Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.

Topics covered include:
- environment, epigenetics and diseases
- DNA methylation and toxicogenomics
- chromatin at the intersection of disease and therapy
- epigenomic actions of environmental arsenicals
- environment, epigenetics and cardiovascular health
- toxicology, epigenetics and autoimmunity
- ocular epigenomics: potential sites of environmental impact in development and disease
- nuclear RNA silencing and related phenomena in animals
- epigenomics – impact for drug safety sciences
- methods of global epigenomic profiling
- transcriptomics: applications in epigenetic toxicology

Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

"Despite some of the issues with the structure, Toxicology and Epigenetics is an important, timely book that provides world-class, expert opinion on a broad range of topics in a fast moving highly relevant branch of toxicology."
- British Toxicology Society, 1 July 2013


Contents

Preface xxi
Acknowledgment xxiii
List of Contributors xxv

1 Introduction 1
2 Environment, Epigenetics, and Diseases 5
3 DNA Methylation and Toxicogenomics 25
4 Chromatin at the Intersection of Disease and Therapy 51
5 Molecular Epigenetic Changes Caused by Environmental Pollutants 73
6 Epigenetic Mediation of Environmental Exposures to Polycyclic Aromatic Hydrocarbons 111
7 Epigenomic Actions of Environmental Arsenicals 129
8 Arsenic-Induced Changes to the Epigenome 149
9 Environmental Epigenetics, Asthma, and Allergy: Our Environment’s Molecular Footprints 191
10 miRNAs in Human Prostate Cancer 205
11 Environment, Epigenetics, and Cardiovascular Health 219
12 Toxicology, Epigenetics, and Autoimmunity 241
13 Toxicoepigenomics in Lupus 261
14 Ocular Epigenomics: Potential Sites of Environmental Impact in Development and
15 Nuclear RNA Silencing and Related Phenomena in Animals 297
16 Epigenetic Biomarkers in Cancer Detection and Diagnosis 317
17 Epigenetic Histone Changes in the Toxicologic Mode of Action of Arsenic 339
18 Irreversible Effects of Diethylstilbestrol on Reproductive Organs and a Current
19 Epigenomics–Impact for Drug Safety Sciences 365
20 Archival Toxicoepigenetics: Molecular Analysis of Modified DNA from Preserved Tissues in Toxicology Studies 387
21 Nanoparticles and Toxicoepigenomics 409
22 Methods of Global Epigenomic Profiling 427
23 Transcriptomics: Applications in Epigenetic Toxicology 445
24 Carcinogenic Metals Alter Histone Tail Modifications 459
25 Prediction of Epigenetic and Stochastic Gene Expression Profiles of Late Effects after Radiation Exposure 475
26 Modulation of Developmentally Regulated Gene Expression Programs through Targeting of Polycomb and Trithorax Group Proteins 511
27 Chromatin Insulators and Epigenetic Inheritance in Health and Disease 539
28 Bioinformatics for High-Throughput Toxico-Epigenomics Studies 569
29 Computational Methods in Toxicoepigenomics 589
30 Databases and Tools for Computational Epigenomics 595
31 Interface of Epigenetics and Carcinogenic Risk Assessment 615
32 Epigenetic Modifications in Chemical Carcinogenesis 631
33 Application of Cancer Toxicoepigenomics in Identifying High-Risk Populations 645

References 651
Index 653


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