The ability of pathogenic bacteria to adapt to various chemical, biochemical and physical conditions within the human host and their ability to respond to stresses generated in these environments is a central feature of infectious diseases and the outcome of bacterial infection. This book covers the key aspects of this rapidly developing field, including the generation of stresses by the host immune system, bacterial response to reactive chemicals, and adaptation to environmental conditions of anatomical niches such as the gut, mouth and urogenital tract. It also addresses the increasing importance of different metal ions in the pathogenesis and survival of specific bacteria. With chapters by active research experts in the field, the book provides a comprehensive outline of the current understanding of this field, the latest developments and where future research is likely to be directed.
"This timely volume fills a significant gap in the literature for a review of the mechanisms of stress tolerance that exist within pathogenic bacteria. It brings together a series of well-written reviews, authored by highly regarded researchers… a very useful volume."
- Microbiology Today, Feb 2012
Part 1: Oxidative and Nitrosative Stress
1. Oxidative and Nitrosative Stress Defence Systems in Escherichia coli and Pseudomonas aeruginosa
2. Coordinated Regulation of Stress and Virulence Adaptations in Stages of Haemophilus Pathogenesis
3. Nitric Oxide Stress in E. coli and Salmonella
4. Nitric Oxide and Gram-positive Pathogens
Part 2: Novel Gene Regulation in Response to Host Defences
5. Novel Regulation in Response to Host-generated Stresses
6. Stress Responses in the Pathogenic Neisseria
Part 3: Acid Stress: pH Control and Survival in the Human Host
7. Acid Survival Mechanisms of Bacterial Pathogens of the Digestive Tract
8. Urease and the Bacterial Acid Stress Response
Part 4: Nutrient Stress
9. Secretion Systems and Metabolism in the Pathogenic Yersiniae
10. Response of Neisseria gonorrhoeae to Oxygen Limitation and Excess
Part 5: Metal Ions and Pathogenic Bacteria
11. Copper and Zinc Stress in Bacteria
12. Metal Ion Sensing in Mycobacterium tuberculosis
13. Salmonella and the Host in the Battle for Iron
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