This book provides background information, guidance for method development, and a discussion of applications in the field of hydrophilic interaction chromatography (HILIC.) The book serves as a valuable reference tool for scientists confronted with an analysis problem involving polar compounds to determine if HILIC would be a good choice to pursue and helps them in choosing initial experimental conditions. The book gives a detailed description of the HILIC retention mechanisms and specific information regarding application areas spanning a wide range of industries.
Chapter 1. Separation Mechanisms in Hydrophilic Interaction Chromatography
Chapter 2. Stationary Phases for HILIC
Chapter 3. HILIC Method Development
Chapter 4. Pharmaceutical Applications of Hydrophilic Interaction Chromatography
Chapter 5. Hydrophilic Interaction Chromatography (HILIC) for Drug Discovery
Chapter 6. Advances in Hydrophilic Interaction Chromatography (HILIC) for Biochemical Applications
Chapter 7. HILIC-MS for Targeted Metabolomics and Small Molecule Bioanalysis
Chapter 8. HILIC for Food, Environmental, and Other Applications
Chapter 9. Theory and Practice of Two-Dimensional Liquid Chromatography Separations Involving the HILIC Mode of Separation
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