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Mutation-Driven Evolution

Authored by a world-renowned specialist in the field
Tackles the core mechanisms of evolution which have remained controversial since Darwin's publication of The Origin of Species
Evaluates the roles of mutation and selection in phenotypic evolution at the molecular level
Adopts a historical perspective to understand the various theories of evolution presented in the past and their relationships with a new theory of mutation-driven evolution proposed in this book
Ideal graduate seminar course material

By: Masatoshi Nei (Author)

248 pages, 4 plates with colour photos and colour illustrations; b/w photos, b/w illustrations, tables

Oxford University Press

Paperback | Oct 2014 | #214149 | ISBN-13: 9780198724100
Availability: Usually dispatched within 6 days Details
NHBS Price: £37.50 $46/€42 approx
Hardback | May 2013 | #202390 | ISBN-13: 9780199661732
Availability: Usually dispatched within 6 days Details
NHBS Price: £62.50 $76/€70 approx

About this book

The purpose of Mutation-Driven Evolution is to present a new mechanistic theory of mutation-driven evolution based on recent advances in genomics and evolutionary developmental biology. The theory asserts, perhaps somewhat controversially, that the driving force behind evolution is mutation, with natural selection being of only secondary importance. The word 'mutation' is used to describe any kind of change in DNA such as nucleotide substitution, gene duplication/deletion, chromosomal change, and genome duplication. A brief history of the principal evolutionary theories (Darwinism, mutationism, neo-Darwinism, and neo-mutationism) that preceded the theory of mutation-driven evolution is also presented in the context of the last 150 years of research. However, the core of Mutation-Driven Evolution is concerned with recent studies of genomics and the molecular basis of phenotypic evolution, and their relevance to mutation-driven evolution. In contrast to neo-Darwinism, mutation-driven evolution is capable of explaining real examples of evolution such as the evolution of olfactory receptors, sex-determination in animals, and the general scheme of hybrid sterility. In this sense the theory proposed is more realistic than its predecessors, and gives a more logical explanation of various evolutionary events.

Mutation-Driven Evolution is suitable for graduate level students as well as professional researchers (both empiricists and theoreticians) in the fields of molecular evolution and population genetics. It assumes that the readers are acquainted with basic knowledge of genetics and molecular biology.

"[T]hose of us involved in evolution education and interested in conceptual issues relevant to evolution have a lot to learn from this book."
– Kostas Kampourakis, Science & Education


1: Selectionism and Mutationism
2: Neo-Darwinism and Pan-Selectionism
3: Evolutionary Theories in the Neo-Darwinian Era
4: Molecular Evolution
5: Gene Duplication, Multigene Families, and Repetitive DNA Sequences
6: Evolution of Phenotypic Characters
7: Mutation and Selection in Speciation
8: Adaptation and Evolution
9: Mutation and Selection in Evolution
10: Summary and Conclusion

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Masatoshi Nei is a molecular evolutionary geneticist and has developed many statistical methods that are widely used for evolutionary studies at present. He has also studied human evolution and evolution of multigene families, immune systems genes, sensory receptor genes, etc. Masatoshi Nei is currently Evan Pugh Professor of Biology at the Pennsylvania State University and is a member of the National Academy of Sciences. He received numerous Awards including the International Prize for Biology from Japan and the Thomas Morgan Medal from the Genetics Society of America. Nei is a co-founder of the journal Molecular Biology and Evolution and served as President of the Society for the Study of Molecular Biology and Evolution and American Genetic Association.

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