Evolutionary genomics is a new field that bridges molecular evolution, bioinformatics and genomics. Part 1 of Introduction to Evolutionary Genomics describes the core processes of replication, transcription and translation, followed by mutation, phylogeny, neutral evolution and natural selection. Part 2 describes genome evolution in prokaryotes, eukaryotes, vertebrates and humans. Part 3 covers genome sequencing, phenotype data collection, databases and homology searches. Part 3 then focuses on nucleotide sequence analysis, including multiple alignments, evolutionary distance computation, phylogenetic tree/network construction and gene genealogy.
The relationships between genome sequences and phenotypes are then discussed, and the final chapter of Part 3 contains worked-out examples of evolutionary genomic studies. The appendices comprise Part 4, which supply historical perspectives and statistical tests in addition to some basic facts, such as genetic code tables, the geological time table, and a brief classification of all organisms.
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Dr. Naruya Saitou is a Professor in the Department of Genetics at the Graduate University for Advanced Studies, and in the National Institute of Genetics, Mishima, Japan. He is also a Professor in the Department of Biological Sciences at the University of Tokyo, Japan.