Now in its fifth edition Biochemistry and Molecular Biology features a new author team, who have retained the much-praised clarity of previous editions, while adding a more biomedical focus and incorporating a discussion of recent developments in research. A new chapter on the general principles of nutrition emphasises the key principles underlying complex metabolic pathways, enabling students to appreciate an integrated view of human metabolism and nutrition. Also new to the fifth edition, a chapter on the control of gene expression reflects our increasing understanding of the importance and power of gene regulation. With an integrated approach covering both biochemistry and molecular biology, complemented by frequent diagrams and clear explanations, and all presented in a broader cellular context, this text is the perfect introduction for any student new to the subject.
New to this edition:
- New chapter on the general principles of nutrition enables students to understand the key principles underlying complex metabolic pathways
- New chapter on the control of gene expression reflects the increasing emphasis on gene regulation in contemporary research
- A strengthened biomedical focus provides extra context to the processes and concepts being described.
- Two new authors, Alison Snape and Despo Papachristodoulou bring additional teaching and research experience in biochemistry and molecular biology to the book.
"Easy to read with good use of simple figures and plenty of internal cross-references to other chapters or relevant pages. I was impressed with the inclusion of some very up to date findings."
– Dr Peter Morris, School of Life Sciences, Heriot-Watt University
"I don't know of any other biology/biochemistry book that explains DNA replication as well as this one"
– Lynn Rogers, School of Molecular and Biomedical Science, Adelaide University
"The style is very clear, logical and systematic. The diagrams complement the text well"
– Dr Momna Hejmadi, Department of Biology and Biochemistry, University of Bath
Part 1: Basic concepts of life
1: The basic molecular themes of life
2: Cells and viruses
3: Energy considerations in biochemistry
Part 2: Structure and function of proteins and membranes
4: The structure of proteins
5: Methods in protein investigation
7: The cell membrane and membrane proteins
8: Muscle contraction, the cytoskeleton, and molecular motors
Part 3: Metabolism and Nutrition
9: General principles of nutrition
10: Food digestion, absorption, and distribution to the tissues
11: Mechanisms of transport, storage, and mobilization of dietary components
12: Principles of energy release from food
13: Glycolysis, the TCA cycle, and the electron transport system
14: Energy release from fat
15: An alternative pathway of glucose oxidation. The pentose phosphate pathway
16: Synthesis of glucose (gluconeogenesis)
17: Synthesis of fat and related compounds
18: Nitrogen metabolism: amino acid metabolism
19: Nitrogen metabolism: nucleotide metabolism
20: Mechanisms of metabolic control and their applications to metabolic integration
21: Raising electrons of water back up the energy scale — photosynthesis
Part 4: Information storage and utilization
22: The genome
23: DNA synthesis, repair, and recombination
24: Gene transcription
25: Protein synthesis and controlled protein breakdown
26: Control of gene expression
27: Protein sorting and delivery
28: Manipulating DNA and genes
Part 5: Cells and tissues
29: Cell signalling
30: The cell cycle, cell division, and cell death
Part 6: Protective mechanisms against disease
32: Special topics: blood clotting, xenobiotic metabolism, reactive oxygen species
33: The immune system
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Dr Alison Snape is Programme Director for the BSc in Biomedical Science and also Senior Lecturer in Biochemistry at King's College London. Her research interests include gene expression and differentiation in early embryonic development. Dr Snape has extensive experience of teaching biochemistry and molecular biology to undergraduates and organises modules for first year students of their BSc Biosciences programmes.
Dr Despo Papachristodoulou is Senior Lecturer in Biochemistry and also Head of Preclinical Medicine at King's College London. Her research interests include diabetes and diabetic complications, insulin metabolism, intermediary metabolism, nutrition, medical education, and curriculum development.