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Behavioral Genetics of the Mouse, Volume 2: Genetic Mouse Models of Neurobehavioral Disorders

Presents the major genetically modified mouse lines used to model human neurobehavioral disorders
Includes the critical review of the validity of many of the existing genetic mouse models of neuropathologies
Each chapter reviews current knowledge about one specific type of disorder, pointing the reader towards the most important studies in the extensive literature

Series: Cambridge Handbooks in Behavioural Genetics Volume: 2

By: Susanna Pietropaolo (Editor), Frans Sluyter (Editor), Wim E Crusio (Editor)

530 pages, 15 b/w illustrations, 31 tables

Cambridge University Press

Hardback | Sep 2014 | #208988 | ISBN-13: 9781107044456
Availability: Usually dispatched within 6 days Details
NHBS Price: £103.00 $126/€116 approx

About this book

The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders; from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.


List of contributors

Part I. Introduction to Genetic Mouse Models of Neurobehavioral Disorders:
1. Introduction Frans Sluyter and Wim E. Crusio
2. Developing mouse models of neurobehavioral disorders: when is a model a good model? F. Josef van der Staay, Saskia Arndt and Rebecca E. Nordquist

Part II. Perception Disorders:
3. Pain disorders Odd-Geir Berge
4. Disorders of the visual system Stewart Thompson and Alisdair R. Philp

Part III. Autonomous and Motor Disorders:
5. Obesity and anorexia Gertjan van Dijk and Martien J. H. Kas
6. Sleep disorders Glenda Lassi and Valter Tucci
7. Cerebellar disorders Robert Lalonde and Catherine Strazielle
8. Motor disorders David Gordon and Kevin Talbot
9. Epilepsy Ortrud K. Steinlein

Part IV. Social Dysfunction and Mental Retardation:
10. Pathological aggression Frans Sluyter, Aki Takahashi and Stephen C. Maxson
11. Disorders of sex Ashlyn Swift-Gallant and Douglas Ashley Monks
12. Autism Valerie J. Bolivar
13. Rett syndrome Laura Ricceri, Bianca De Filippis and Giovanni Laviola
14. Fragile X syndrome Susanna Pietropaolo and E. Subashi
15. Attention-deficit hyperactivity disorder Tatyana D. Sotnikova and Raul R. Gainetdinov
16. Obsessive-compulsive disorder and Gilles de la Tourette's syndrome Nancy S. Woehrle and Stephanie C. Dulawa
17. Schizophrenia Sofya Abazyan and Mikhail V. Pletnikov
18. Down syndrome Mara Dierssen
19. Prader–Willi and Angelmann syndromes Emily Y. Smith and James L. Resnick
20. Williams syndrome Lucy R. Osborne and Zhengping Jia

Part V. Anxiety and Mood Disorders:
21. Anxiety disorders Guy Griebel and Sandra Beeské
22. Depression Christopher R. Pryce and Federica Klaus
23. Bipolar disorder Nirit Kara and Haim Einat

Part VI. Substance Dependence and Abuse:
24. Alcohol use disorders John C. Crabbe
25. Drug abuse: nicotine Rebecca C. Steiner and Marina R. Picciotto
26. Cannabis abuse and dependence Tim Karl and Jonathon C. Arnold
27. Drug abuse: amphetamines Tamara J. Phillips, Emily C. Eastwood and John H. Harkness
28. Cocaine-related disorders F. Scott Hall and Ichiro Sora
29. Opioids-related disorders Angelo Contarino

Part VII. Neurodegenerative Disorders:
30. Alzheimer's disease Christopher Janus and David Borchelt
31. Parkinson's disease Iddo Magen and Marie-Françoise Chesselet
32. Huntington's disease Yoon H. Cho and Susanna Pietropaolo


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Susanna Pietropaolo is currently a researcher at the French National Research Council (CNRS). She is an expert in the behavioral analysis of the laboratory mouse, with a special interest in inter-specific social behaviors. Her recent research focuses on mouse models of social dysfunction, including autism and Fragile X Syndrome.

Frans Sluyter is an expert in (wild) house mouse behavior and neurogenetics. His interests range from aggression, addiction, depression and (stress) coping strategies to gene expression profiles and consciousness.

Wim E. Crusio is a Research Director at the French National Research Council (CNRS). With over 35 years experience in mouse behavioral neurogenetics and the phenotyping of mouse behavior, his recent interests cover mouse models of depression, autism and Fragile X Syndrome.

- Frans Sluyter
- Wim E. Crusio
- F. Josef van der Staay
- Saskia Arndt
- Rebecca E. Nordquist
- Odd-Geir Berge
- Stewart Thompson
- Alisdair R. Philp
- Gertjan van Dijk
- Martien J. H. Kas
- Glenda Lassi
- Valter Tucci
- Robert Lalonde
- Catherine Strazielle
- David Gordon
- Kevin Talbot
- Ortrud K. Steinlein
- Aki Takahashi
- Stephen C. Maxson
- Ashlyn Swift-Gallant
- Douglas Ashley Monks
- Valerie J. Bolivar
- Laura Ricceri
- Bianca De Filippis
- Giovanni Laviola
- Susanna Pietropaolo
- E. Subashi
- Tatyana D. Sotnikova
- Raul R. Gainetdinov
- Nancy S. Woehrle
- Stephanie C. Dulawa
- Sofya Abazyan
- Mikhail V. Pletnikov
- Mara Dierssen
- Emily Y. Smith
- James L. Resnick
- Lucy R. Osborne
- Zhengping Jia
- Guy Griebel
- Sandra Beeské
- Christopher R. Pryce
- Federica Klaus
- Nirit Kara
- Haim Einat
- John C. Crabbe
- Rebecca C. Steiner
- Marina R. Picciotto
- Tim Karl
- Jonathon C. Arnold
- Tamara J. Phillips
- Emily C. Eastwood
- John H. Harkness
- F. Scott Hall
- Ichiro Sora
- Angelo Contarino
- Christopher Janus
- David Borchelt
- Iddo Magen
- Marie-Françoise Chesselet
- Yoon H. Cho

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