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Bupleurum Species: Scientific Evaluation and Clinical Applications

Discusses the botany, pharmacology, quality control and clinical usage of Bupleurum with named and defined polyherbal formulations
Offers particular focus on the saikosaponins of the oleanane series, which are shown to be especially medically relevant
Describes a variety of constituents in detail including lignans, flavonoids, coumarins, polyacetylenes, phenyl propanides, and polysaccharides (those with antiulcer, antitumor, and immunomodulating properties
Details the geographical distribution of 19 species and 2 varieties
Tabulates and discusses 222 different constituents of essential oils derived from the plants

Series: Traditional Herbal Medicines for Modern Times

By: Sheng-Li Pan (Editor)

272 pages, 22 b/w photos, 108 b/w illustrations, 55 tables

CRC Press

Hardback | Apr 2006 | #210554 | ISBN: 0849392659
Availability: Usually dispatched within 6 days Details
NHBS Price: £82.99 $101/€93 approx

About this book

The prominence of the Bupleurum species cannot be overstated. Across China and Japan, it serves as a main or supplementary ingredient in over two thirds of traditional medications. For over 2000 years, it has been used to treat fevers, intestinal maladies, malaria, and countless other afflictions. Modern research indicates that it may possess anti-tumor qualities, and researchers continue to report its impact on a wide range of ailments, from hepatitis and epilepsy, to irregularity and menopause, as well as psychosis and schizophrenia. Bupleurum Species: Scientific Evaluation and Clinical Applications brings together the work of leading researchers from Asia and Europe who examine this remarkable genus of plants.

Providing a comprehensive look at all aspects relevant to the species, this historic volume:
- Examines the botany of the species, including detailed descriptions of the plant parts used in medicine
- Discusses cultivation worldwide, looking at how environmental factors influence plant content
- Details its chemistry and biology, covering plants in Asia, as well as Spain and Italy
- Explores what is currently understood about its pharmacology
- Looks at its effectiveness in clinical applications, including a summary of recent findings on its use as a treatment for septic shock
- Provides the most complete compendium available on patents containing Bupleurum, listing over 500, and detailing each one's application and inventor

Edited by the renowned Sheng-Li Pan, who has discovered six new species of Bupleurum, this important work should be considered required reading for those who wish to explore the properties of this remarkable natural product, along with its proven and potential applications. It has also been effectively organized as a reference for those involved with the application and research of natural products, as well as botanists and those employed with drug discovery and development.

"This text is the first of its kind and should prove quite useful for those interested in the properties and applications of this ubiquitous natural product. It is well organized and should serve as an excellent reference for botanist, natural products chemists, and those involved with drug discovery."
- Kathleen M. Halligan in Journal of Natural Products, 2007, Vol. 70, No. 1


Introduction; Sheng-Li Pan

I. Botany: Macroscopical Characters of the Medicinal Species of Bupleurum and Their Distribution in China; Sheng-Li Pan and Yun Kang
- Microscopical Characters of the Medicinal Species of Bupleurum in China; Sheng-Li Pan
- Chromosomes of Bupleurum L. Especially for the Classification and Cross-Breeding of B. falcatum L. sensu lato; Shigeki Ohta, Eiji Miki, You-Chang Zhu, and Chang-Qi Yuan

II. Cultivation: Cultivation of Bupleurum falcatum in Japan; Osamu Iida
- Distribution of Saikosaponin of Bupleurum falcatum and Variation of Its in Plant Organs by Environmental Factors; Nak-Sul Seong, Hae-Gon Chung, and Kwan-Su Kim

III. Chemistry: Main Chemical Constituents of Bupleurum Genus; Sheng-Li Pan
- The Chemistry and Biological Activity of the Genus; Bupleurum in Spain; Alejandro F. Barrero, M. Mar Herrador, Pilar Arteaga, and José F. Quílez
- The Chemistry and Biological Activity of the Genus Bupleurum in Italy; Luisa Pistelli

IV. Pharmacology: The Pharmacological Activity of Chinese "Chaihu" - The Root of Bupleurum; Xiao-Min Du, Hui Xie, and Yun Kang
- Pharmacological Activity of Saikosaponins; Byung-Zun Ahn and Dai-Eun Sok
- Mitogenic Substance of Bupleuri Radix; Naohito Ohno and Toshiro Yadomae

V. Clinical Application: Clinical Applications of Prescriptions Containing Bupleurum Root; Bai-Can Yang and Jun Wang
- Anti-Hepatofibrotic Effect of Xiao-Chaihu-Tang (Sho-Saiko-To); Ichiro Shimizu
- Preventive Effects of Sho-Saiko-To against Septic Shock Symptoms; Shuhei Sakaguchi

VI. Patents Containing Bupleurum

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