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Regenerative Biology of the Eye

Explores current knowledge on stem cell application for vision loss
Showcases different types of stem cells (adult, embryonic, iPSCs) for diseases of the front and back of the eye
Highlights data obtained in various models from fish to human, as well as from the bionic eye project for vision regeneration

Series: Stem Cell Biology and Regenerative Medicine

By: Alice Pébay (Editor)

410 pages, 26 colour & 6 b/w illustrations, 8 tables


Hardback | Jun 2014 | #214441 | ISBN-13: 9781493907861
Availability: Usually dispatched within 1-2 weeks Details
NHBS Price: £123.00 $151/€138 approx

About this book

Regenerative Biology of the Eye covers visual regenerative biology from current knowledge through future directions and implications. Fifteen chapters discuss the topic thoroughly, from fundamental aspects of developmental biology of the eye through the potential of stem cells and bionic eyes to improve and restore vision. Regenerative Biology of the Eye also explores the impact of stem cell treatments and regenerative medicine in society.

The economic and public health burdens of blindness are immense, in addition to the psychological and social implications for patients. While current treatments for blindness are limited, regenerative medicine offers exciting prospects for vision improvement or restoration, instilling hope in patients suffering from vision loss. Authoritative and timely, Regenerative Biology of the Eye is a key resource for scientists working in this expanding and dynamic field.


1 Understanding Retina Development Can Inform Future Regenerative Therapies
Peter D. Westenskow
2 Mitochondria in retinal neurodegeneration and stem cell models
Ian A. Trounce
3 The regenerative potential of the vertebrate retina - lessons from the zebrafish
Jeremy Ng, Peter D. Currie, Patricia R. Jusuf
4 Stem Cells and Regeneration in the Xenopus Retina
Magdalena Hidalgo, Morgane Locker, Albert Chesneau, Muriel Perron
5 Advances in Pluripotent and Adult Stem Cells for Eye Research
Gary S.L. Peh, Raymond C.B. Wong
6 Stem cell strategies for optic nerve protection
Alessia Tassoni, Keith R. Martin
7 Stem cell strategies for diseases of the outer retina
Alex W. Hewitt, Kathryn C. Davidson
8 Potential of Muller cells and stem/progenitor cells to regenerate retinal tissue
Marius Ader, Volker Enzmann, Mike Francke
9 Stem cells and the ocular lens: implications for cataract research and therapy
Patricia Murphy, Michael D. O'Connor
10 Trabecular Meshwork Stem Cells
Hongmin Yun, Joel S. Schuman, Yiqin Du
11 Stem Cells of the Human Corneoscleral Niche
Samuel McLenachan, Dan Zhang, Fred K. Chen
12 Advances on optic nerve regeneration and therapeutic strategies
Silmara de Lima, Yoshiki Koriyama, Takuji Kurimoto, Larry I. Benowitz
13 Bionic Eyes: Vision Restoration through Electronic or Photovoltaic Stimulation
Lauren N. Ayton, Robyn H. Guymer, Penelope J. Allen, Chi D. Luu
14 Stem Cell-Derived RPE Transplantation for Age-Related Macular Degeneration: Experimental Studies to Improve Transplant Survival and Differentiation
Ilene K. Sugino, Qian Sun, Noounanong Cheewatrakoolpong, Christopher Malcuit, Marco A Zarbin
15 Seeing The Full Picture: The Hidden Cost Of The Stem Cell And Regenerative Medicine Revolution
Claire Tanner, Megan Munsie

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Alice Pébay Ph.D. is the principal investigator of the Neuroregeneration Unit at the Centre for Eye Research Australia, and a Senior Research Fellow in the Department of Ophthalmology at the University of Melbourne. She holds a Ph.D. in neuroscience and has extensive expertise in cell biology, having published more than 40 peer reviewed articles and chapters in the field of stem cell biology and lysophospholipid biology. Dr Pebay's current research focuses on the mechanisms that enable human pluripotent stem cells to maintain their pluripotency and allow them to differentiate towards specific retinal lineages. Dr Pébay also has comprehensive experience in neurotrauma research and a strong interest in the cellular mechanisms involved in the genetic disease, Friedreich Ataxia.

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