Books  Animal & General Biology  Biochemistry & Molecular Biology 

Extracellular Matrix in Development

Gives a comprehensive and up to date overview on the field
Written by experts in the field
Covers the role of ECM in development from all angles

Series: Biology of Extracellular Matrix Series

By: Douglas W DeSimone (Editor), Robert P Mecham (Editor)

263 pages, 37 colour & 4 b/w illustrations

Springer-Verlag

Hardback | Mar 2013 | #219157 | ISBN-13: 9783642359347
Availability: Usually dispatched within 1-2 weeks Details
NHBS Price: £141.50 $180/€166 approx

About this book

Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information.

Extracellular Matrix in Development discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.


Contents

Part I Informational signals in extracellular matrix and matrix influences on cell movement in the developing embryo
Part II Extracellular matrix-direct morphogenesis, growth factor signaling, and maintenance of the stem cell niche
Part III Model organisms and the lexicon of developmental signals associated with the extracellular matrix


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