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Animal Models in Toxicology

Provides a single source reference for the use of animal models in toxicology
Includes new chapters on telemeterized animals and imaging, and a section on transgenic animals has been added to the mouse chapter.
Individual chapters cover the major species used in toxicology and experimental biology
Reviews current laws and regulations governing animal care and use in major countries
Contains extensive appendices of acronyms, regulatory and scientific web sites, animal suppliers, and a lexicon of terms used in describing clinical signs

Series: Drug and Chemical Toxicology Series Volume: 8

By: Shayne C Gad (Editor)

1096 pages, 261 b/w illustrations, 98 tables

CRC Press

Hardback | Sep 2015 | Edition: 3 | #224054 | ISBN-13: 9781466554283
Availability: Usually dispatched within 6 days Details
NHBS Price: £114.00 $145/€136 approx

About this book

Biomedical science's use of animals as models help us understand and predict responses in humans in toxicology and pharmacology, yet their use remains a source of significant controversy. Animal Models in Toxicology, Third Edition, explores the many facets of the use of animal models in toxicology. Individual chapters cover the major species and review current laws and regulations governing animal care and use in major countries.

This edition of Animal Models in Toxicology includes new chapters on telemeterized animals and imaging and adds a section on transgenic animals. Animal Models in Toxicology, Third Edition also contains extensive appendices of acronyms, regulatory and scientific websites, animal suppliers, and a lexicon of terms.


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Contents

Introduction
Shayne Cox Gad
The Mouse
Shayne Cox Gad, Charlie Clifford, and Dawn Goodman
The Rat
Mark D. Johnson, Shayne Cox Gad, and Christopher J. Kemper
The Hamster
Shayne Cox Gad and Frederick G. Hess
The Guinea Pig
Shayne Cox Gad
Rabbit
Clare M. Salamon and Shayne Cox Gad
The Ferret
Daniel E. McLain and Shayne Cox Gad
The Dog
Shayne Cox Gad, Mark Morse, and Christopher J. Kemper
Primates
Mark D. Walker, Michael V. Templin, John C. Bernal, Stewart B. Jacobson, and Shayne Cox Gad
The Minipig
Shayne Cox Gad and Alain Stricker-Krongrad
Alternative Species
Shayne Cox Gad
Clinical Pathology of Laboratory Animals
Niraj K. Tripathi and Robert L. Hall
New! Telemetry in Nonclinical Drug Safety Assessment Studies
R. Dustan Sarazan
New! Molecular Imaging Techniques in Laboratory Animals
Zheng J. Wang, Ting-Tung A. Chang, Richard Slauter, Stephen R. Porter, Avinash Srivatsan, and Xiaoyuan Chen
New! Genetically Modified Animal Models
JoAnn C.L. Schuh
Model Selection and Scaling (Allometry)
Shayne Cox Gad
Susceptibility Factors
Shayne Cox Gad
Laws, Regulations, and Guidelines for Animal Care and Use in Research
Charles B. Spainhour
New! Necropsy and Gross Pathology
Charles B. Spainhour
New! Immunology Laboratory Endpoints for Assessment of Immunomodulators in Preclinical Studies and Case Studies Using Anti-CD3 mAb in Cynomolgus Monkey
Lynne LeSauteur, Simon Lavallee, and Marie-Soleil Piché
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