Books  Animal & General Biology  Biochemistry & Molecular Biology 

Induction of Bone Formation in Primates: The Transforming Growth Factor

Discusses basic research in the area and moves on to the future role of the TGF-beta isoform in the clinic, including some human studies
Looks at the redundancy of bone induction signaling and possible synergies between the TGF-beta and BMP families of growth factors
Covers the isolation and cloning of the beta-3 isoform

By: Ugo Ripamonti (Editor)

240 pages, 49 b/w illustrations, 1 table

Apple Academic Press Inc.

Hardback | Dec 2015 | #224231 | ISBN-13: 9781482216165
Availability: Usually dispatched within 7 days Details
NHBS Price: £134.00 $164/€151 approx

About this book

The effects of the bone morphogenetic protein family (BMP) of growth factors on bone formation are well documented, but the TGF-beta isoforms are much less studied and have the potential to shed light on the apparent redundancy of bone induction signalling. This edited book – Induction of Bone Formation in Primates – sums up the editor's 15 years of research into the osteogenic activity of the TGF-beta growth factor family, particularly in primates.

Induction of Bone Formation in Primates awakens skeletal reconstructionists, tissue engineers, and molecular and cellular biologists to the profound and important bone inductive activity of the hTGF-β3 isoform.


- Preface
- Introduction
- Regenerative medicine, bone tissue engineering and the osteogenic proteins of the transforming growth factor-β (TGF-β) supergene family
- The induction of bone formation by bone morphogenetic proteins and other members of the TGF-β supergene family
- The biological significance of redundancy: The induction of bone formation by the mammalian transforming growth factor-β1 and -β2 in non-human primates
- Isolation and molecular cloning of the transforming growth factor-β3 isoform
- Rapid induction of bone formation in non-human primates by the transforming growth factor-β3 isoform
- Regeneration of mandibular defects in non-human primates by the transforming growth factor-β3
- Mandibular reconstruction in humans with recombinant human transforming growth factor- β3
- Synergistic induction of bone formation by low doses of TGF-β1 and TGF-β3 with recombinant human osteogenic protein-1 (hOP-1), bone morphogenetic protein-7 |
- Perspectives of hTGF-β3 in regenerative medicine and bone tissue engineering

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