612 pages, 92 colour & 184 b/w illustrations, 11 tables
Marine Biomedicine: From Beach to Bedside assesses current efforts in marine biomedicine and evaluates the implications of recent advances on the future of the field.
Richly illustrated in full color to enhance reader comprehension, Marine Biomedicine covers four sections. The first one addresses the technology that has recently been brought to bear on the study of marine natural products, including omics and bioinformatic techniques. The second focuses on lead discovery and reviews various products and their biomedical potential.
Examples of clinically successful marine products and discussions of approaches to the clinic are presented in the third section while the last section discusses prospects for the future of marine biodiscovery.
Highlighting new technologies, this valuable resource provides an overview of both what is currently possible in the field as well as a detailed look at what is being done in marine natural products research.
MARINE BIOTECHNOLOGY: INFORMING THE SEARCH
Accessing Chemical Diversity through Metagenomics
Leah C. Blasiak and Russell T. Hill
Chemical Characterization of Marine Organisms Using a Metabolomic Approach
Kashif Ali, Robert Verpoorte, Erica G. Wilson, and Young Hae Choi
Biosynthetic Approaches to Marine Drug Discovery and Development
Eric W. Schmidt
Dereplication of Natural Products Using Databases
MARINE BIODISCOVERY: LEAD DISCOVERY
Logistic Considerations to Deliver Natural Product Libraries for High-Throughput Screening
Ngoc B. Pham, Stephen Toms, David Camp, and Ronald J. Quinn
Screening Marine Microbial Libraries
Jacqueline L. von Salm, Christopher G. Witowski, Danielle H. Demers, Ryan M. Young, Laurent Calcul, and Bill J. Baker
Screening Strategies for Drug Discovery and Target Identification
Fatma H. Al-Awadhi, Lilibeth A. Salvador, and Hendrik Luesch
Anti-Infective Agents from Marine Sources
Screening for Antiparasitic Marine Natural Products
Ryan M. Young and Eva-Rachele Pesce
Central Nervous System Modulators from the Oceans
Kh. Tanvir Ahmed, Neil Lax, and Kevin Tidgewell
Marine Organisms in Cancer Chemoprevention
Eun-Jung Park, Anam Shaikh, Brian T. Murphy, and John M. Pezzuto
Off the Beaten Path: Natural Products from Extreme Environments
Samantha M. Gromek, Ashley M. West, and Marcy J. Balunas
Bioprospecting Fungi and the Labyrinthulomycetes at the Ocean-Land Interface
Ka-Lai Pang, Clement K. M. Tsui, E. B. Gareth Jones, and Lilian L. P. Vrijmoed
Medicinal Chemistry and Lead Optimization of Marine Natural Products
James W. Leahy
MARINE PRODUCTS IN BIOMEDICINE
The Travails of Clinical Trials with Marine-Sourced Compounds
David J. Newman and Gordon M. Cragg
Conopeptides, Marine Natural Products from Venoms: Biomedical Applications and Future Research Applications
Baldomero M. Olivera, Helena Safavi-Hemami, Martin P. Horvath, and Russell W. Teichert
Development and Commercialization of a Fully Synthetic Marine Natural Product Analogue, Halaven (Eribulin Mesylate)
Charles E. Chase, Hyeong-wook Choi, Atsushi Endo, Francis G. Fang, and John D. Orr
Marine Natural Products in Pharma: How Industry Missed the Boat
Guy T. Carter and Valerie S. Bernan
In Vitro Model for Defining Neurotoxicity of Anticancer Agents
Balanehru Subramanian, Halina Pietraszkiewicz, Joseph E. Media, and Frederick A. Valeriote
PROSPECTS FOR THE FUTURE OF MARINE BIODISCOVERY
Comments on the Past and Future of Marine Natural Product Drug Discovery
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Edited by Bill J. Baker is a professor of chemistry and director of University of South Florida's Center for Drug Discovery and Innovation in Tampa. He earned a BS in chemistry from Cal Poly in San Luis Obispo, California, and his PhD from the University of Hawaii. Dr. Baker conducted postdoctoral research with Ron Parry at Rice University and Carl Djerassi at Stanford University. He is currently visiting Beaufort professor of marine biodiscovery at the National University of Ireland Galway. His research interests in marine natural product chemistry have taken him all over the globe, including 12 field seasons of research in Antarctica.