Snake bites are a major health concern, especially in tropical countries. Understanding the pathology of envenomation and chemical composition of snake venoms is important in the development of medical countermeasures (including, but not limited to, antivenoms). Furthermore, snake venoms can be considered natural "combinatorial libraries" of proteins and peptides. Thus, it is not surprising that components of snake venom have been found extensively useful in biomedical research as well as clinical use for treating diseases as diverse as cancer and muscle pain.
In Snake Venoms & Envenomation, well-known scientists from the Americas, Asia, and Europe discuss recent trends and outlooks in regards to snake venom research. A distinctively broader coverage of the subject is given, with topics ranging from protein biochemistry to pathology.
Several chapters highlight protein biochemistry and enzymology of snake venoms, immune response to envenomation and antivenoms, production and use of snake venom components as antigens for antivenom preparation, and the therapeutic value of snake venom components in the treatment of various diseases.
A comprehensive and authoritative monograph, Snake Venoms & Envenomation will be equally interesting to both established researchers and graduate students interested in toxinology and pathology of envenomation. (Imprint: Nova)
Chapter 1 - Snakes: Diversity, Epidemiology and Envenomation (pp. 3-22)
Authors / Editors: (Priscila Hess Lopes, Carla Cristina Squaiella-Baptistão, Giselle Pidde Queiroz, Denise V. Tambourgi, Immunochemistry Laboratory, Butantan Institute, São Paulo, SP, Brazil)
Chapter 2 - Venoms from “Non-Venomous” Snakes: Rear-Fanged Snake Venoms as Sources of Novel Compounds (pp. 23-52)
Authors / Editors: (Stephen P. Mackessy and Anthony J. Saviola, University of Northern Colorado, School of Biological Sciences, Greeley, Colorado, USA, and others)
Chapter 3 - Venom Production in the 21st Century (pp. 53-66)
Authors / Editors: (Kristen L Wiley and James R Harrison, Kentucky Reptile Zoo, Slade, KY, USA)
Chapter 4 - Extending the use of Snake Venoms to Therapeutics (pp. 69-92)
Authors / Editors: (Paul Reid, Celtic Biotech Inc, West Des Moines, IA, USA)
Chapter 5 - Pathophysiological Significance and Therapeutic Implications of Russell’s Viper Venom Proteins and Peptides affecting Blood Coagulation (pp. 93-114)
Authors / Editors: (Rupamoni Thakur and Ashis K. Mukherjee, Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, Assam, India, and others)
Chapter 6 - Venom Peptide Antagonists of the Nicotinic Acetylcholine Receptor do not Prevent Fatal Encephalitis in the Hamster Model of Rabies (pp. 115-128)
Authors / Editors: (Laurence N. Raymond, Paul F. Reid, Boonlert Lumlertdacha, Felix R. Jackson, Richard Franka, Receptopharm, Inc., Plantation, FL, USA, and others)
Chapter 7 - Immune Response Triggered by Snake Venoms: Impact of Venom Compounds on the Envenomation Process (pp. 131-150)
Authors / Editors: (Carla Cristina Squaiella-Baptistão, Giselle Pidde Queiroz, Priscila Hess Lopes, Denise V. Tambourgi, Immunochemistry Laboratory, Butantan Institute, São Paulo, SP, Brazil)
Chapter 8 - Antivenoms (pp. 151-166)
Authors / Editors: (Milind V. Khadilkar, Premium Serums & Vaccines Pvt.Ltd., Maharashtra, India)
Chapter 9 - Evolution, Structural Features, and Biochemical Diversity of Snake Venom Serine Proteinases (pp. 169-214)
Authors / Editors: (Monika A.Coronado, Raphael J. Eberle, Fábio R. de Moraes, Jorge H. Fernandez, E.P. Gomes, A. Lira1, Raghuvir K. Arni, Multiuser Center for Biomolecular Innovation, Department of Physics, IBILCE/UNESP, São Jose do Rio Preto-SP, Brazil, and others)
Chapter 10 - Cytotoxicity of Snake Venoms and Toxins: Mechanisms and Applications (pp. 215-254)
Authors / Editors: (Nget Hong Tan and Choo Hock Tan, Department of Molecular Medicine; bDepartment of Pharmacology, Faculty of Medicine, Univerity of Malaya, Kuala Lumpur, Malaysia)
Chapter 11 - Purine – a “Multitoxin” Release Related Enzymes of Snake Venom in Envenomation: An Overview (pp. 255-282)
Authors / Editors: (Bhadrapura L. Dhananjaya, Toxinology/Toxicology and Drug Discovery Unit, Center for Emerging Technologies, Jain Global Campus, Jain University, Kanakapura Taluk, Ramanagara, Karnataka, India)
Chapter 12 - Commentary: The Promise of Snake Genomics (pp. 283-288)
Authors / Editors: (Michael K. Richardson and R. Manjunartha Kini, Institute of Biology, University of Leiden, The Netherlands, and others)
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