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The Metabotropic Glutamate Receptors offers state-of-the-art summaries and reviews of virtually everything known today about metabotropic glutamate receptors (mGluRs), including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. Illuminating the overall role played by this crucial class of receptors in brain function, the book also pinpoints those areas in which there is the greatest continuing need for focused research. Because mGluRs have the potential for participating in virtually all known functions of the central nervous system (CNS), the opportunity now exists to develop pharmacological agents that can potentially alter many brain disease processes by selective interaction with precise CNS functions. With its critical and insightful reviews, The Metabotropic Glutamate Receptors will immediately become your essential key to the development of novel treatment strategies for the widest variety of neurological disorders.
Molecular Cloning Expression and Characterization of Metabotropic Glutamate Receptor Subtypes. Pharmacological Properties of Metabotropic Glutamate Receptors. Second-Messenger Systems Coupled to Metabotropic Glutamate Receptors in Mammalian Brain. Anatomical Distribution of Metabotropic Glutamate Receptors in Mammalian Brain. Modulation of Ionic Currents by Metabotropic Glutamate Receptors in the CNS. Acute Regulation of Synaptic Transmission by Metabotropic Glutamate Receptors. Long-Lasting Modulation of Synaptic Transmission by Metabotropic Glutamate Receptors. Regulation of Neuronal Circuits and Animal Behavior by Metabotropic Glutamate Receptors. Roles of Metabotropic Glutamate Receptors in Neuronal Degeneration. Plasticity of Metabotropic Glutamate Receptors in Physiological and Pathological Conditions. Index.
...gives a state-of-the-art in the field (and) points out the needs of future research. - Trends in Pharmacological Sciences Review
