Molecular Biology of tRNA Structure, Biosynthesis and Function

About this book

Provides an account of all aspects of research on transfer RNA, including its structure, biosynthesis, and interactions with the many proteins involved in protein biosynthesis.

Contents

Transfer RNA after four decades; tRNA: discovery, early work and total synthesis of tRNA genes; Structure and expression of prokaryotic tRNA genes; Transcription of eukaryotic tRNA genes; tRNA processing nucleases; Recent studies of RNase P; Splicing of tRNA precursors; Primary, secondary and tertiary structure of tRNAs; Organellar tRNAs: biosynthesis and function; tRNA-like structures in plant viral RNAs; Biosynthesis and function of modified nucleosides; Modified nucleosides and codon recognition; tRNA sequences and variations in the genetic code; Aminoacyl-tRNA synthetases: occurrence, structure and function; Bacterial aminoacyl-tRNA synthetases: genes and regulation of expression; The tRNA identity problem: past, present and future; Small RNA oligonucleotide substrates for specific aminoacylations; tRNA discrimination in aminoacylation; Recognition in the glutamine tRNA system: from structure to function; The aspartic acid tRNA system: recognition by a class II aminoacyl-tRNA synthetase; Recognition of aminoacyl-tRNAs by protein elongatin factors; tRNA on the ribosome: a waggle theory; Discontinuous triplet decoding with or without re-pairing by peptidyl tRNA; Translational suppression: when two wrongs do make a right; Initiator tRNAs and initiation of protein synthesis; The selenocysteine-inserting tRNA species: structure and function; Glutamyl-tRNA as an intermediate in glutamate conversions

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