Part 1 Physiological roles of protease: participation of lysosomal cathepsins in antigen processing and bone resorption, N. Katunuma; the refined X-ray crystal structures of human and rat liver cathepsin B, W. Bode et al; a novel calpain species, n-calpain, active at nM levels of calcium?, H. Sorimachi and K. Suzuki; human cysteine proteinases and their inhibitors, stefins and cystatins, V. Turk and W. Bode; molecular recognition of proteases associated with cascade reactions, M. Sasaki and I. Ohkubo; the expression and structure of rat cystatin beta gene, N. Sato et al; meprins and other members of the "Astacin Family" of metalloendopeptidases, W. Jiang and J.S. Bond; biosynthesis, processing, and localization of cathepsin E, K. Yamamoto et al; proteasome and ubiquitin-dependent proteolysis, K. Tanaka and A. Ichihara; turnover of heat-shock proteins, H. Holzer et al. Part 2 Pathogenesis and protease: alterations in processing and trafficking of cathepsin B during malignant progression, B.F. Sloane et al; viral proteases - a personal odyssey, B.D. Korant; proteolysis-induced pathomechanisms in acute inflammation and related therapeutic approaches, M. Jochum et al; neutral proteases of human mast cells, L.B. Schwartz; a processing protease for gp 160 HIV-1 envelope glyco-protein precursor in human T4+ lymphocytes, H. Kido et al; fibrinogen - a plasma protein of many functions, E.W. Davie et al; mechanisms for alteration of the proteinase-proteinase inhibitor balance in tissues, J. Travis; snake venom haemorrhagic and non-haemorrhagic metalloproteinases - their structure and function relationships, H. Takeya and S. Iwanaga; inactivation and fragmentation of alpha 1-protease inhibitor by Cu, Zn-superoxide dismutase and hydrogen peroxide via liberation of hydroxyl radical, H. Maeda et al.