Toxicology of Aflatoxins Human Health, Veterinary and Agricultural Significance

About this book

Aflatoxins, natural fungal toxins found in foods and animal feeds, have great public health significance. This book presents the basic and applied toxicology of aflatoxins, including analytical identification, agricultural and veterinary implications, toxicology and carcinogenesis in humans, and economic and regulatory problems associated with aflatoxin contamination and control. Key features include: molecular mechanisms of aflatoxin toxicity; analytical issues in sampling and analysis; regulatory and economic issues associated with aflatoxin contamination of food and feed; and presentation of human and animal toxicology, veterinary, and agricultural issues related to aflatoxin contamination.

Contents

Experimental Toxicology of Aflatoxins: Acute Effects: Acute Hepatoxicity of Aflatoxins. Biochemical Mechanisms and Biological Implications of the Toxicity of Aflatoxins as Related to Aflatoxins Carcinogenesis. Biological Disposition of Aflatoxins: Biotransformation of Aflatoxins. Pharmacokinetics and Excretion of Aflatoxins. Non-Hepatic Effects and Biotransformations. Carcinogenicity and Mutagenicity of Aflatoxins: Carcinogenicity in Non-Mammalian Organisms. Role of DNA Adducts in the Cancer Process. On the Mechanisms By Which Aflatoxin Carcinogenesis in the Context of the Multistage Nature of Cancer. Nutritional Modulation of Aflatoxin Carcinogenesis. Human Carcinogenicity and Toxicity: The Epidemiology of Aflatoxin-Related Disease. Molecular Dosimetry Methods for Assessing Human Aflatoxin Exposure. Strategies for Chemoprotection Agains Aflatoxin-Induced Liver Cancer. Agricultural and Veterinary Problems: Factors Affecting Aspergillus Flavus Group Infection and Aflatoxin Contamination of Crops. Mycological Aspects of Aflatoxin Formation. Veterinary Diseases Related to Aflatoxins. Aflatoxins in Milk. Approaches to Reductions of Aflatoxins in Foods and Feeds. Analytical Identification of Aflatoxins: Recent Methods for the Quantitation of Aflatoxins in Foods and Feeds. Problems Associated with Accurately Measuring Aflatoxins in Foods and Feeds: Errors Associated with Sampling, Sample Preparation, And Analysis. Development of Antibodies for Aflatoxins. Economic and Regulatory Aspects of Aflatoxins: Human Risk Assessment Based on Animal Data: Inconsistencies and Alternatives. Economic Issues Associated with Aflatoxins.

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