Tracing Biological Evolution in Protein and Gene Structures

About this book

Proceedings of the 20th Taniguchi International Symposium on Biophysics, held in Nagoya, Japan in 1994. This book comprises original articles on recent research into the following: the modular design and assembly of protein and RNA molecules; the structures and activities of modular units; the relationship of modular designs to the evolution of biological systems for information transfer and the decoding of genetic information.

Contents

Implications of an operational RNA code for amino acids, P. Schimmel; dissection of an enzyme into two fragments at intron-exon boundaries, K. Shiba; architectures of class I aminoacyl-tRNA synthetases, O. Nureki and S. Yokoyama; structure, function and evolution of aminoacyl-tRNA synthetases, S. Cusak; module structure and function of glutamyl-tRNA synthetase, M. Tateno et al; ribosomal RNA in pieces - a modern paradigm of the primordial ribosome, M.W. Gray et al; structure and function of RNA-binding proteins in chloroplasts and cyanobacteria, M. Sugita et al; mechanism of alternative RNA splicing, K. Inoue and Y. Shimura; spliceosomal introns in the spliceosomal small nuclear RNA genes, T. Tani et al; the "tetrahymena" ribozyme tolerates diverse activator domains that replace P5abc, Y. Ikawa et al; aminoacyl tRNA synthetase and polymerase - modular design and evolution, T.A. Steitz et al; thermodynamics of RNA/DNA hybrid formation, N. Sugimoto; using sequence variation to model RNA three-dimensional structures, R. Cedergren; modules of barnase - the physicochemical basis for their structures, T. Noguti and M. Go; mechanical stability of protein modules determined by molecular dynamics simulations, K. Takahashi et al; helix-turn-helix module distribution and module shuffling, K. Yura and M. Go; module replacement converted coenzyme specificity of isocitrate dehydrogenase, T. Oshima et al; the chimeric nature of nuclear genomes and the antiquity of introns as demonstrated by the GAPDH gene system, R. Cerff; putative origin of introns deduced from protein anatomy, M. Go and T. Noguti; tests of the exon theory of genes, W. Gilbert et al; domain evolution of serine protease and its inhibitor genes, T. Gojobori et al; sketch of landscapes in the protein sequence space around catalase I from "bacillus stearothermophilus", T. Yomo et al; correlation between module boundaries and intron positions in hemoglobins from various taxa, K. Fukami-Kobayashi et al; module substitution in globins - preparation and association characteristics of chimeric hemoglobin subunits and myoglobin, K. Wakasugi et al; three-dimensional profiles - assessing the compatibility of an amino acid sequence with a three-dimensional structure, J.U. Bowie et al.

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