About this book
During this century we have experienced a shift in the leading causes of death from infectious diseases, such as pneumonia and influenza, to chronic diseases, such as heart disease and cancer. Whereas infectious diseases are often related to a single infectious agent, chronic diseases are often related to a combination of environmental (including occupational) chemical exposures and genetic factors.This valuable reference helps the reader to identify these chemical pollutants in environmental matrices such as air, water, food, and soil. It provides improved analytical methods to measure the pollutant, its metabolites, and its various possible adducts in humans. This book presents the latest work designed to assess potential exposure (environmental concentration and activity of pollutants), dose to humans, and a molecular basis for some of the affected biological mechanisms.
Contents
Mutational Spectra and Other Microbiological Processes Monitoring Microbial Pathogens and Indicator Microorganisms in Water Using the Polymerase Chain Reaction and Gene Probe Methods, R.M. Atlas, A.K. Bej, J.L. DiCesare, L.A. Haff, and S. McCarty Allele-Specific Hybridization and Polymerase Chain Reaction (PCR) in Mutation Analysis: The Salmonella Typhimurium his Paradigm, T.A. Cebula Mutational Spectra of the Four Bay Region Diol Epoxides of Benzo[c]Phenanthrene and the Drinking Water Mutagen, MX, Determined with an Improved Set of E. coli lacZ- Mutants, C. Lu, H. Yagi, D.M. Jerin, and A.M. Cheh Assessment of Gene Expression in the Environment: Quantitative mRNA Analysis in Contaminated Soils, J.T. Fleming and G.S. Sayler Biological and Biochemical Evidence of Strand-Specific Repair of DNA Damage Induced in Human Cells by (A )-7b,8a-Dihydroxy-9a,10a-Epoxy-7,8,9,10-Tetrahydrobenzo[a]pyrene,V.M. Maher, R.-H. Chen, and J.J. McCormick Molecular Analysis of Frameshift Mutations Induced by Plant-Activated 2-Aminofluorene, M.J. Plewa, M.J. Timme, D. Cortez, S.R. Smith, and E.D. Wagner Identification of Sulfate-Reducing Bacteria by Hydrogenase Gene Probes and Reverse Sample Genome Probing, G. Voordouw, A.J. Telang, T.R. Jack, J. Foght, P.M. Fedorak, and D.W.S. Westlake The Uses and Abuses of Immunological Testing, D.K. Flaherty Human Cytochromes P-450 and Their Roles in Environmentally Based Disease, F.J. Gonzales Biomonitoring and Bioanalytical Chemistry Important Considerations in the Ultratrace Measurement of Volatile Organic Compounds in Blood, D.L. Ashley, M.A. Bonin, F.L. Cardinali, J.M. McCraw, J.V. Wooten, and L.L. Needham Applications of New HPLC/MS Techniques in Human Biomonitoring, W.M. Draper, F.R. Brown, R.A. Bethem, M.J. Miille, and C.E. Becker Measurement of Reductive Dechlorination of Pentachlorophenol by Actinomyces viscosus Strain dechlorini by GC/MS Techniques, F.O. Bryant and H.G. Cutler A Versatile Bioluminescent Reporter System for Organic Pollutant Bioavailability and Biodegradation, A. Heitzer, O.F. Webb, P.M. DiGrazia, and G.S. Sayler Analytical Method for Biomonitoring of Aniline in Urine and Comparison with the Classical Calorimetric Method, R. Orth, G. Spies, R. Nair, and J.M. Wendling Biological Monitoring of Workers Exposed to Triazine Herbicides: I. Determination of Simazine and Its Metabolites in Urine, J.G. Guillot, A. Leblanc, O. Samuel, and J.P. Weber Biological Monitoring of Workers Exposed to Triazine Herbicides: II. Presentation of a Method for the Determination of Hexazinone and Its Main Metabolites in Urine of Exposed Forestry Workers, A. LeBlanc, O. Samuel, J.G. Guillot, and J.P. Weber
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