About this book
This work attempts to cover most advances made in the classical genetics and, in particular, recent molecular genetics of the ascomycetous filamentous fungi Aspergillus. Although emphasis is placed on Aspergillus nidulans, the book encompasses other aspergilli, especially species of industrial interest. Aspergillus nidulans classical genetic research started during World War II by Pontecorvo and has been a firm favourite with researchers from very different fields as a vehicle, due to its genetic manipulative ability. Its popularity has increased even more due to recent molecular technology. The scope of the book is fairly wide, embracing a wide variety of topics, for example, from general metabolism and its regulation through sexual and asexual differentiation to biotechnology. Most of the major Aspergillus research players have contributed articles. This text is recommended to researchers working in any field of mycology since the Aspergillus research is usually at the leading edge of mycological work.
Contents
Part 1 Introduction: the early history, A. Roper; humble beginnings at Glasgow university, E. Forbes; pedigree of the authors, S.D. Martinelli; aspergillus nidulans as an experimental organism, S.D. Martinelli. Part 2 Metabolism and its control: carbon metabolism in aspergilli, D.A. Hondmann and J. Visser; alcohol metabolism, B. Felenbok and H.M. Sealy-Lewis; inorganic nitrogen assimilation - molecular aspects, J.R. Kinghorn and S.E. Unkles; control of metabolic flux in the shikimate and quinate pathways, A.R. Hawkins et al; the purine degradation pathway, genetics, biochemistry and regulation, C. Scazzocchio; the proline utilization pathway, history and beyond, C. Scazzocchio; regulation of acetamide utilization, M.J. Hynes; sulphur metabolism, A. Paszewski et al. Part 3 Global gene regulation: nitrogen metabolite repression, M.X. Caddick; carbon catabolite repression, J.M. Kelly; regulation of gene expression by oxygen, phosphorus and pH, H.N. Arst. Part 4 Development, morphology and organelles: genetic regulation of conidiation, W.E. Timberlake and A.J. Clutterbuck; sexual sporulation, S.P. Champe et al; control of cell growth, J.H. Doonan; ribsomes, S.D. Martinelli; mitochondria, T.A. Brown. Part 5 Applied aspects: heterologous gene expression and protein secretion in aspergillus, W. Davies; economically important organic acid and enzyme products, E.A. Bodie et al; penicillin biosynthesis, J.M. Luengo and M.A. Penalva. Part 6 Molecular tools: vectors for genetic manipulation, G. Turner; molecular characterization of chromosomes by pulsed field electrophoresis, G.L. Carter et al. Part 7 Further topics: homologous recombination, F. Osman et al; translational suppression, S.D. Martinelli; phenoloxidases, G.W. Griffith. Part 8 Appendices: linkage map and loci, A.J. Clutterbuck; gene symbols, S.D. Martinelli; media, S.D. Martinelli; source of strains and vectors, S.D. Martinelli.
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