Books  Animal & General Biology  Biochemistry & Molecular Biology 

Eukaryotic DNA Replication

Series: Frontiers in Molecular Biology Volume: 15

Edited By: JJ Blow

210 pages, 1 col plate, 5 b/w photos, 53 line illus

IRL Press

Paperback | Aug 1996 | #56012 | ISBN: 0199635854
Availability: Usually dispatched within 2-3 weeks Details
NHBS Price: £69.99 $89/€83 approx
Hardback | Dec 1996 | #56013 | ISBN: 0199635862
Out of Print Details

About this book

A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge of interest in the subject. This book is intended for postgraduate students, postdoctoral researchers, and academic staff. Possibly some third-year undergraduate readership.


"This volume is largely successful in capturing the key issues of the eukaryotic DNA replication field, including enzymology of the replication fork, the structure of replication origins, and the regulation of DNA replication, and in summarizing recent progress. An attractive feature of the volume is the juxtaposition of chapters that highlight contributions from the genetically tractable budding and fission yeasts with chapters that highlight contributions of the more biochemical and cell biological approaches necessary in Xenopus and mammalian cells." --Science
"Eight thoughtful reviews with clear figures and diagrams written by experts in the field. Together, these reviews provide a framework for thinking about cellular DNA replication in which students, teachers, and researchers should be able to integrate developments in this fast-moving field." --Science
"Provides a current survey of research. . . .A generally well-written, heavily referenced, and well illustrated work


Contents

1. Enzymology of the replication fork; 2. SV40 DNA replication; 3. The initiation of DNA replication in the year Saccharomyces cerevisiae; 4. Replication origins in metazoan chromosomes; 5. Role of nuclear structure in DNA replication; 6. Chromosome replication in Xenopus egg extracts; 7. Cell cycle control of DNA replication in Saccharomyces cerevisiae; 8. Regulation of S phase in the fission yeast Schizosaccharomyces pombe

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