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Structure in Protein Chemistry

By: Jack Kyte

898 pages, Illus, tabs, figs

Garland Science

Hardback | Jul 2006 | Edition: 2 | #183356 | ISBN: 0815338678
Availability: Usually dispatched within 6 days Details
NHBS Price: £81.00 $103/€96 approx
Hardback | Dec 1995 | #64633 | ISBN: 0815317018
Availability: Usually dispatched within 6 days Details
NHBS Price: £71.00 $91/€84 approx

About this book

The second edition of "Structure in Protein Chemistry" showcases the latest developments and innovations in the field of protein structure analysis and prediction. The book begins by explaining how proteins are purified and describes methods for elucidating their sequences of amino acids and defining their posttranslational modifications. Comprehensive explanations of crystallography and of noncovalent forces - ionic interactions, hydrogen bonding, and the hydrophobic effect - act as a prelude to an exhaustive description of the atomic details of the structures of proteins. The resulting understanding of protein molecular structure forms the basis for discussions of the evolution of proteins, the symmetry of the oligomeric associations that produce them, and the chemical, mathematical, and physical basis of the techniques used to study their structures.


Contents

1. Purification 2. Electronic Structure 3. Sequence of Polymers 4. Crystallographic Molecular Models 5. Noncovalent Forces 6. Atomic Details 7. Evolution 8. Counting Polypeptides 9. Symmetry 10. Chemical Probes of Structure 11. Immunochemical Probes of Structure 12. Physical Measurements of Structural Shape 13. Folding and Assembly 14. Membranes

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Biography

Jack Kyte, Professor Emeritus in the Chemistry Department at the University of California in San Diego, is well known for his research on the analysis of protein structure. He graduated magna cum laude from Carleton College with a degree in Chemistry. Under the tutelage of Guido Guidotti, he received his graduate degree in the Department of Biochemistry and Molecular Biology at Harvard University in Cambridge Massachusetts. Prof. Kyte joined the Department of Chemistry at the University of California at San Diego in 1974. Prof. Kyte has had a major impact in the prediction and analysis of protein structure. He ran a laboratory investigating the structure and mechanism of sodium and potassium ATPase, an enzyme from plasma membranes responsible for active transport; acetylcholine receptor, a protein in the plasma membrane that transports cations; the receptor for epidermal growth factor, a protein in the plasma membrane that controls cellular growth; and ribonucleotide reductase, a cytoplasmic enzyme responsible for the conversion of ribonucleotides into deoxyribonucleotides. This research was funded by grants from the National Institutes of Health, the National Science Foundation, and the American Heart Association. Prof. Kyte received a Career Development Award from the National Institutes of Health, and served on the editorial board of Biochemistry for six years.

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