The Many Faces of RNA

About this book

Explores RNA as a therapeutic target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.

Contents

Introduction. Overview: RNA as a Therapeutic Target for Bleomycin, S.M. Hecht. RNA: Chemistry, Structure and Interactions: Synthetic RNA Modification and Cross-linking Approaches towards the Structure of the Hairpin Ribozyme and the HIV-1 Tat Protein Interaction with TAR RNA, M.J. Gait, D.J. Earnshaw, M.A. Farrow, and N.A. Naryshkin. The Ribosome - The Universal Protein-synthesizing Machine, R. Brimacombe. tRNA Recognition by Aminoacyl-tRNA Synthetases, S. Cusack, A. Yaremchuk, and M. Tukalo. RNA-Protein Recognition During RNA Processing and Maturation, G. Varani. RNA as a Target/RNA as a Tool: Exploiting RNA: Potential Targets, Screens and Drug Development, C.D. Prescott, L. Hegg, K. Nurse, R. Gontarek, H. Li, V. Emerick, T. Sterner, M. Gress, G. Thom, S. Guth, and D. Rispoli. Structural Basis for Aminoglycoside Antibiotic Action, J.D. Puglisi. Protein-RNA Recognition in a Highly Conserved Ribosomal Domain Targeted by Thiazole Antibiotics, D.E. Draper. Rnase P and Its Substrate, L.A. Kirsebom. Interfering with Gene Function at the RNA Level with Oligoymes - the Development of New Tools and Therapeutics, B.S. Sproat, S.T. George, M. Ma, and A.R. Goldberg. Progress towards Therapeutic Application of SELEX-derived Aptamers, B. Polisky. Catalysis of Organic Reactions by RNA - Strategies for the Selection of Catalytic RNAs, A. Jaschke. Conclusions and Opportunities, B.W. Metcalf. Appendix: Abstracts of Posters. Index.

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