This is an exciting and stimulating volume which uses the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting levels at which genes can be regulated. Areas discussed in detail include the role of chromosomal domains in gene silencing, the parameters that determine the activity of transgenes in plants and animals, the host defence mechanisms that protect organisms from the danger of integrating foreign DNA into their chromosome, and the importance of genomic imprinting in development and human disease.
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