Oxford Handbook of Nucleic Acid Structure

About this book

The Oxford Handbook of Nucleic Acid Structure is a comprehensive reference text on all aspects of nucleic acid sturcture. Particular emphasis is placed on the results from X-ray crystallography and NMR studies, with both methods being given equal weight. The nineteen chapters describe in detail the variety of DNA and RNA structural types discovered to date with all the major 'native' structures being represented. The text progresses systematically through the polymorphs of double helical DNA through to the higher-order organizations of triplexes, quadruplexes, and junctions, then to RNA structures in their various degrees of complexity. Each chapter has been written by authorities in the field who have worked together to provide this comprehensive text on nucleic acid structure. The whole project has been brought together and edited by Professor Stephen Neidle who is Director of the CRC Biomolecular Structure Unit at the Institute of Cancer Research.

Contents

1. [data missing]; 2. Polynucleotide secondary structures: an historical perspective; 3. Base and base pair morphologies, helical parameters, and definitions; 4. The nucleic acid database: a research and teaching tool; 5. Simulation of nucleic acid structure; 6. A-DNA duplexes in the crystal; 7. Helix structure and molecular recognition by B-DNA; 8. The single-crystal structures of Z-DNA; 9. Standard DNA duplexes and RNA-DNA hybrids in solution; 10. Nucleic acid hydration; 11. Single crystal X-ray diffraction studies on the non Watson-Crick base associations of mismatches, modified bases, and non-duplex oligonucleotide structures; 12. DNA mismatches in solution; 13. Structures on nucleic acid triplexes; 14. [data missing]; 15. DNA bending by adenine-thymine tracts; 16. Structures and interactions of helical junctions in nucleic acids; 17. DNA higher-order structures; 18. Crystallographic structures of RNA oligoribonucleotides and ribozymes; 19. RNA structure in solution; 20. Transfer RNA

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