Books  Animal & General Biology  Biochemistry & Molecular Biology 

Lysosomal Cysteine Proteases

Series: Protein Profile Series

By: Heidrun Kirschke, Alan J Barrett and Neil D Rawlings

144 pages, Line figs, tabs

Oxford University Press

Paperback | Mar 1998 | Edition: 2 | #83579 | ISBN: 0198502494
Availability: Usually dispatched within 2-3 weeks Details
NHBS Price: £84.99 $107/€100 approx

About this book

This volume examines each known cathepsin in turn, examining gene structure and localization; precursors, purification, activation and inhibition; and hydrolysis of synthetic substrates, polypeptides and proteins.


"This book would be a worthwhile addition to the library of anyone with an interest in lysosomal proteinases.--Doody's Journal
"This book is part of a series that provides comprehensive data on the structure, kinetics and biochemistry of individual families of proteins. The current book focuses on the major family of mammalian lysosomal cysteine proteinases that are related by sequence and structure to papain. Biochemical details of cathepsins B, H, K, L, and S and dipeptidyl peptidase are clearly presented. An unrelated lysosomal cysteine proteinase, legumain, is also discussed briefly. The structural section gives useful lists of important amino acids that play significant roles in both the structure and catalytic specificity of the enzymes. . . . [A] succinct, readable review of the lysosomal cysteine proteinases. The bibliography occupies more than half of the book, and lists 1830 references that cover all areas of research on mammalian lysosomal cysteine proteinases, making


Contents

Function; kinetic and biochemical properties; sequences, sequence relationships and sequence features; domain structure; mutations; 3-D structure; building sites; ligand-binding sites and drug interqaction; derivitization sites; proteolytic cleavage sites.

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