Discovering Molecular Genetics A Case Study Course with Problems and Scenarios

About this book

Fully illustrated undergraduate textbook offering a case-study approach, based on analysis of classic and recent papers and discussion of the lives of the principal investigators concerned. It contains introductory essays which review the key concepts, and over 180 questions, with answers, test factual knowledge derived from each section. Thoroughly recommended for microbiology, biochemistry, molecular biology, or biology students.

Contents

Part 1 Classical papers: historical perspective; the structure of DNA, Watson and Crick. The fine structure of the gene: Benzer's study of the fine structure of the gene. The nature of the genetic code: general nature of the genetic code for proteins, Crick et al. Decoding the amber and ochre triplets: the nature of nonsense codons; deciphering amber and ochre triplets, Brenner at al. The search for colinearity: on the colinearity of gene structure and protein structure, Yanofsky et al. Conjugation and genetic recombination: nature of gene transfer in bacterial conjugation, Wollman et al. Genetic regulatory mechanisms: genetic regulatory mechanisms in the synthesis of proteins, Jacob et al. In vivo genetic engineering: transposition of the lac genes; prophage lambda at unusual chromosomal locations, Beckwith et al. Structure-function relationships in proteins: studies of Hemoglobin, Perutz et al. Part 2 Updated papers. Mutagenesis: hotspots for deletions and frameshifts; the specicifity of mutagens, Farabaugh et al. Transposable elements: characterization of transposition; use of transposons as mutagenic agents; mechanism of transposition, Hedges et al. Part 3 Questions, answers, problems and scenarios.

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