Books  Animal & General Biology  Biochemistry & Molecular Biology 

Cytokine Knockouts

Handbook / Manual

Series: Methods in Molecular Biology

By: Scott K Durum and Kathrin Muegge

Humana Press

Hardback | Dec 1998 | #86612 | ISBN: 0896033686
Availability: Usually dispatched within 1-2 weeks Details
NHBS Price: £94.00 $118/€112 approx

About this book

This book is a unique compendium of the latest information on cytokine knockouts. Each chapter - written by the leading scientists who created or studied each knockout - illuminates the physiological consequences of deficiency in a particular cytokine and relates the phenotype to other knockout mice and to human diseases. The effects discussed range from diseases of the bowel, lung, heart, blood, kidney, and liver to immune deficiency, developmental defects, and autoimmunity. Most of the key knockouts of cytokines or receptors, including IL-1 through 8, IFNs, TGFs, TNF, LT, CD40, LIF, CSFs, c-mpl, gp130, and ICE, are thoroughly reviewed.

...should be the most useful for everybody who wants to learn about those thrilling, novel leads into the biology of the immune system and the pathogenesis of human diseases. - from the Foreword by Klaus Rajewsky, Institute of Genetics, Cologne ...a very nice compendium of research in a very important area ... should be on the shelves of all life science and biomedical libraries. - 5 Stars, Doody's Health Sciences Book Review Journal


Contents

The IL-2 Deficiency Syndrome: A Lethal Disease Caused by Abnormal Lymphocyte Survival T. H?nig and A. Schimpl. IL-7 Knockout Mice and the Generation of Lymphocytes U. von Freeden-Jeffry T. A. Moore A. Zlotnik and R. Murray. Lymphoid Development and Function in IL-7R-Deficient Mice J. J. Peschon B. C. GliniakP. Morrissey and E. Maraskovsky. CD40 Ligand Knockout Mice C. R. Maliszewski M. K. Kennedy and K. A. Campbell. Physiological Immunological and PathologicalFunctions of Tumor Necrosis Factor (TNF) Revealed by TNF Receptor-Deficient Mice H. Bluethmann. Cooperation Between the TNF Receptors Demonstrated by TNF Receptor Knockout Mice E. Shinbrot and M. Moore. Immunodeficiency of Tumor Necrosis Factor and Lymphotoxin-a Double-Deficient Mice H.-P. Eugster M. M?ller M. Le Hir and B. Ryffel. Characterization of Lymphotoxin a-Deficient Mice T. A. Banks. Interleukin-1b- Deficient Mice G. Fantuzzi and C. A. Dinarello. Functional Phenotype of Mice Deficient in the IL-1R Type 1 Gene: A Comparison with Other Genetically Modified Mice P. J. Morrissey M. GlaccumC. R. Maliszewski and J. Peschon. Mice Deficient in Interleukin-1b Converting Enzyme K. Kuida J. A. Lippke M.S.-S. Suand R. A. Flavell. Neutrophilia and B-Cell Plasmacytosis in Mice Lacking the Murine IL-8 Receptor Homolog M. W. Moore and G. Cacalano. Knockouts of Interferons Interferon Receptors and Interferon Signaling Components J. Vilcek M. Aguet and L. F. L. Reis. IL-6 Gene Knockout Mice A. J. Ramsay and M. Kopf. IL-6 Unique Functions in InflammationBone Metabolism and B-Cell Neoplasias Revealed by Studies on IL-6 Deficient Mice V. Poli. Myocardial Hematological and Placental DisordersCaused by Targeted Disruption of gp130 A Common Signal Transducer for IL-6 Family of Cytokines K. Yoshida T. Taga M. Saito A. Kumanogoh T. Tanaka K. Ozono M. Nakayama T. Nakahata N. Yoshida and T. Kishimoto. NF-IL6 Knockout Mice S. Akira T. Tanaka and T. Kishimoto. Disruption of the LIF Receptor C. B. Ware and J. S. Hunt. Phenotypes of TGFb Knockout Mice S. Kallapur M. Shulland T. Doetschman. The Transforming Growth Factor-b1 Knockout Mouse:The Phenotype and Its Implicationsfor TGFb1 Function A. B. Kulkarni and J. J. Letterio. Granulocyte-Macrophage Colony-Stimulation Factor(GM-CSF)-Deficient Mice A. R. Dunn and G. J. Lieschke. The In Vivo Role of the Receptors for IL-3 GM-CSF and IL-5 (bc and bIL3) R. Nishinakamura S. Burdach U. Dirksen and R. Murray. Granulocyte Colony- Stimulating Factor(G-CSF)-Deficient Mice G. J. Lieschke and A. R. Dunn. Reduction of Platelets and Megakaryocytesin c-mpl-Deficient Mice M. W. Moore and F. J. de Sauvage.

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