This book is a unique compendium of the latest information on cytokine knockouts. Each chapter - written by the leading scientists who created or studied each knockout - illuminates the physiological consequences of deficiency in a particular cytokine and relates the phenotype to other knockout mice and to human diseases. The effects discussed range from diseases of the bowel, lung, heart, blood, kidney, and liver to immune deficiency, developmental defects, and autoimmunity. Most of the key knockouts of cytokines or receptors, including IL-1 through 8, IFNs, TGFs, TNF, LT, CD40, LIF, CSFs, c-mpl, gp130, and ICE, are thoroughly reviewed.
...should be the most useful for everybody who wants to learn about those thrilling, novel leads into the biology of the immune system and the pathogenesis of human diseases. - from the Foreword by Klaus Rajewsky, Institute of Genetics, Cologne ...a very nice compendium of research in a very important area ... should be on the shelves of all life science and biomedical libraries. - 5 Stars, Doody's Health Sciences Book Review Journal
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