Books  Animal & General Biology  Biochemistry & Molecular Biology 

The Nicotinic Acetylcholine Receptor: Current Views and Future Trends

Edited By: FJ Barrantes

Springer-Verlag

Hardback | Dec 1998 | #95736 | ISBN: 3540642587
Availability: Usually dispatched within 1-2 weeks Details
NHBS Price: £138.50 $175/€164 approx

About this book

Different techniques from various disciplines have made possible the analysis of the structure and the multiplicity of functions performed by ligand- and voltage-gated ion channels and receptors. This book covers one of the fastest growing fields in the molecular neurosciences - that of the ligand-gated ion channels (LGIC). Future trends, which are analyzed in each chapter, encompass the likely strategies for decoding structure-function relationships of the receptor molecule, the establishment of the differences in ionic selectivity and the mechanisms of permeability through the pore, and the possible use of genetic kindredness between actylcholine receptors of different species for the diagnosis of new genetic diseases.


Contents

Evolution of the nicotinic acetylcholine receptor (NAR) and other rapid-ligand gated channels * Ligand binding properties of the NAR * Adding up the energies in the acetylcholine receptor channel: relevance to allosteric therory * Ionic conductance through the NAR * Neuronal nicotinic receptors * Molecular modeling of the NAR * Molecular pathology of the NAR.

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