Concepts in Eukaryotic DNA Replication

About this book

This book, which includes the first fourteen chapters of the acclaimed monograph DNA Replication in Eukaryotic Cells (see page 32), is a broad account of the basic principles of DNA replication and related functions such as DNA repair and protein phosphorylation. It also includes a newly commissioned chapter in which the editor, Mel DePamphilis, provides a review of the most recent advances in understanding the complex gene and protein interactions that underpin this essential cellular function. DNA Replication in Eukaryotic Cells has been acclaimed as "...an absolute must for anyone working in the DNA replication field" (Trends in Cell Biology), "...highly significant addition to the replication literature" (Trends in Biochemical Sciences) and "...an invaluable addition for libraries...the first place to stop for anyone wishing to enter the eukaryotic replication field" (The Quarterly Review of Biology). This abridged edition is ideal for graduate students or established investigators who need a complete and timely introduction to this rapidly advancing field of research.

Contents

Mechanisms for replicating DNA; origins of DNA replication; roles of transcription factors in DNA replication; roles of nuclear structure in DNA replication; mechanisms for priming DNA synthesis; mechanisms for completing DNA replication; fidelity of DNA replication; DNA excision repair pathways; chromatin structure and DNA replication - implications for transcriptional activity; roles of phosphorylation in DNA replication; control of S phase; temporal order of DNA replication; changes in DNA replication during animal development; comparison of DNA replication in cells from prokarya and eukarya; DNA replication in eukaryotic cells - 1998 to 1998.

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