Part 1 Introduction: patterns of cellular activities based on protein sorting in cell motility, endocytosis and cytokinesis. Part 2 Motile responses: new depths in cell behaviour - reactions of cells to nanotopography; self-organization of tissue-equivalents - the nature and role of contact guidance; extracellular regulation of cancer invasion - the E-cadherin/cantenin and other pathways. Part 3 Signal transduction: towards a structure model of an integrin; integrin-mediated cell adhesion - the cytoskeletal connection; Wnt factors in axonal remodelling and synaptogenesis; Rho family proteins and cell migration; Rho-like GTPases - their role in cell adhesion and invasion. Part 4 Cytoskeletal dynamics: microtubule involvement in regulating cell contractility and adhesion-dependent signalling - a possible mechanism for polarization of cell motility; organization and polarity of actin filament networks in cells - implications for the mechanism of myosin-based cell motility; network contraction model for cell translocation and retrograde flow; centrosomes, microtubules and cell migration; cell migration as a five-step cycle. Part 5 Dynamics of motility: cytoskeletal protein mutations and cell motility in "Dictyostelium"; cell crawling two decades after Abercrombie; using molecular genetics as a tool in understanding crawling cell locomotion in myoblasts; forces in cell locomotion. Part 6 Prospects: a dozen questions about how tissue cells crawl.