Books  Animal & General Biology  Biochemistry & Molecular Biology 

DNA Viruses

Handbook / Manual

Edited By: Alan J Cann

272 pages, 23 b/w illus, 15 line illus

Oxford University Press

Paperback | Oct 1999 | #99103 | ISBN: 0199637180
Availability: Usually dispatched within 2-3 weeks Details
NHBS Price: £70.00 $89/€84 approx
Hardback | Oct 1999 | #99104 | ISBN: 0199637199
Out of Print Details

About this book

DNA Viruses: A Practical Approach groups together the major experimental methods currently employed to study DNA viruses, from the fundamentals of virus culture to novel techniques such as surface plasmon resonance spectrometry and realtime PCR analysis of drug resistance mutations in clinical isolates. Chapter 1 provides an overview of the extraction, purification and characterizations of virus DNA, but also covers the fundamentals of DNA virus culture. Chapters 2 and 3 describe approaches to the molecular investigation and mutagenesis of DNA virus genomes. Chapter 4 considers DNA virus replication and then chapters 5 & 6 describe methods to study transcription control. Chapters 7 to 9 consider aspects of the pathogenesis of DNA virus infections. The final chapter describes the current technology being applied to the development of DNA virus vectors for gene delivery. This volume will therefore be of interest to all those working on DNA viruses whether in academia, industry or clinical research.


Contents

Preface; 1. Extraction, purification and characterization of virus DNA; 2. Investigation of DNA virus genome structure; 3. Mutagenesis of DNA virus genomes; 4. Interactions between viral and cellular proteins during DNA virus replication; 5. Analysis of transcriptional control in DNA virus infections; 6. Identification and analysis of trans-acting proteins involved in regulation of DNA virus gene expression; 7. Interaction of DNA virus proteins with host cytokines; 8. Analysis of DNA virus proteins involved in neoplastic cell transformation; 9. Chemotherapy of DNA virus infections; 10. Herpes simplex virus and adenovirus vectors

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