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About this book
Comprehensive and up-to-date source dealing with the latest developments in the field of combinatorial chemistry placing special emphasis on organic chemistry and biochemistry. It covers an interesting variety of synthetic and analytical topics.
Contents
Combinatorial Chemistry; survey of solid phase organic reactions; solid phase combinatorial chemistry; combinatorial chemistry of multicomponent reactions; solid phase anchors in organic chemistry; the use of templates in combinatorial chemistry for solid phase synthesis of multiple core structure libraries; combinatorial synthetic oligomers; glycopeptide and oligosaccharide libraries; RNA and DNA aptamers; combinatorial approaches to molecular receptors for chemosensors; peptide libraries in T-cell mediated immune response; combinatorial biosynthesis of microbial metabolites; design and diversity analysis of compound libraries for lead discovery; how to scale-up while scaling down - EVOscreen, a miniaturized ultra high throughput screening system; high throughput experimentation in catalysis; FT-infrared spectroscopy and IR-microscopy for on bead analysis of compound libraries; mass spectrometric analysis of combinatorially generated compounds and libraries; ion-cyclotron-resonance-FT-mass spectrometry for elemental composition analysis of library components; automation in combinatorial synthesis.
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