672 pages, Illus, figs, tabs
Dynamics of Bone and Cartilage Metabolism is a comprehensive treatise that spans the complete range from basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. Part I of the book provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components, including the important regulators such as cytokines, growth factors, and proteases. The second part of the book covers the organizational structure and cellular metabolism of bone and cartilage. As with the first part, there are separate sections on bone and cartilage addressing their specific and unique functions. For bone, questions on mineralization, remodeling and hormonal regulation are covered as well as the derivation of products of metabolism: for cartilage, the physiology and pathology are reviewed in relation to the products of metabolism, together with recent data from animal and in vitro models. The first two parts of the book serve to contextualize all of the biochemical markers for assessing bone and cartilage metabolism. Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease, both in experimental and clinical settings. A wide range of disorders affecting bone and cartilage metabolism is covered, including different forms of osteoporosis, metastatic bone disease and arthritic diseases, as well as some of the less common growth and degenerative abnormalities. This application-oriented part of the book is complemented by an initial section detailing the methodological and technical aspects of the various biochemical and genetic markers of disease and their measurements. With contributions from over 75 international experts, this book will be indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of the patient with bone and cartilage diseases.
The close developmental and spatial relation between bone and cartilage is self-evident, yet these two issues are often considered as separate entities. The approach taken in theis book--to consider the structural, functional, metabolic, and pathologic aspects of bone and cartilage in parallel--is a welcome departure and provides the reader with an unusual and interesting range of topics... Scientists and physicians who wish to cross the divide between bone and cartilage will find this book of considerable interest and value. There is excellent coverage of the structural and physiologic characteristics of these tissues and detailed descriptions of the methods involved in assessing tissue markers of metabolism in body fluids. --Juliet E. Compston, University of Cambridge, UK, in THE NEW ENGLAND JOURNAL OF MEDICINE (April 20, 2000)
There are currently no reviews for this product. Be the first to review this product!