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Structure and Mechanism in Protein Science: A Guide to Enzyme Catalyst and Protein Folding

Out of Print

By: Alan Fersht

631 pages, Figs, tabs

W.H. Freeman & Co. Ltd

Hardback | Feb 1999 | #104203 | ISBN: 0716732688
Out of Print Details

About this book

By concentrating on fundamental principles and the physical and chemical processes behind them, Structure and Mechanism in Protein Science makes the basic formulas, Kinetics, and thermodynamics of protein engineering easier to understand and apply. Up-to-date, authoritative, and full of relevant examples, it provides a solid introduction to a sprawling, still-growing field.


Contents

The three-dimensional structure of proteins; chemical catalysis; the basic equations of enzyme kinetics; measurement and magnitude of enzymatic rate constants; the pH dependence of enzyme catalysis; practical kinetics; detection of intermediaries in reactions by kinetics; stereochemistry of enzymic reactions; active-site-directed and enzyme-activated irreversible inhibitors - affinity labels and suicide inhibitors; conformational change, allosteric regulation, motors and work; forces between molecules, and enzyme-substrate binding energies enzyme-substrate complementarity and the use of binding; energy in catalysis; specificity and editing mechanisms; recombinant DNA technology; case studies of enzyme structure and mechanism; protein engineering; protein stability; kinetics of protein folding; folding pathways and energy landscapes.

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